Skoči na glavni sadržaj

Recenzija, Prikaz slučaja

Bone Remodeling and Thyroid Function

Velimir Altabas
Maja Berković
Branko Bečejac
Miljenko Solter


Puni tekst: engleski pdf 468 Kb

str. 41-47

preuzimanja: 1.059

citiraj


Sažetak

Many diseases are associated with more rapid bone loss and an increased risk of osteoporosis and fractures. Both hyperthyroidism and hypothyroidism as well as use of thyroid hormones or thyrosuppressant treatment influence bone turnover rates and may alter the risk of future fractures. Markers of bone remodeling are good indicators to determine bone turnover rates and potential bone loss, and correlate well with thyroid hormone levels. Untreated hyperthyroidism accelerates bone turnover resulting in net bone loss, while untreated hypothyroidism in adult humans slows down bone turnover resulting in net bone gain. In both cases, damage in bone microarchitecture occurs, leading to an increased relative risk of fractures. Effective therapies for both states are available, and in ideal case, full recovery of mineralized tissue may occur over time. Controversies are still present in patients receiving suppressive thyroxin treatment for thyroid carcinoma. It seems that suppressed thyroid-stimulating hormone with normal levels of peripheral thyroid hormones may increase the relative fracture risk in postmenopausal but not in premenopausal women. However, the exact molecular mechanisms of thyroid hormone and thyroid-stimulating hormone action on bone are not completely understood yet.

Ključne riječi

Biliopancreatic diversion – methods; Obesity, morbid – surgery; Gastrectomy – methods; Body weight; Weight loss; Case report

Hrčak ID:

12711

URI

https://hrcak.srce.hr/12711

Datum izdavanja:

30.3.2007.

Podaci na drugim jezicima: hrvatski

Posjeta: 3.310 *