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Simultaneous plasmid integration: a unifying model of multiple plasmid integration into the yeast chromosome

PETAR T. MITRIKESKI   ORCID icon orcid.org/0000-0002-8859-3490 ; 1_Laboratory for Evolutionary Genetics Division of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia; 2_Institute for Research and Development of Sustainable Ecosystems, Ivana Lučića 5 (CTT-FSB) HR-10000, Zagreb, Croat
ANA ŠIMATOVIĆ ; Laboratory for Evolutionary Genetics Division of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia
KRUNOSLAV BRČIĆ-KOSTIĆ ; Laboratory for Evolutionary Genetics Division of Molecular Biology, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia

Puni tekst: engleski, pdf (684 KB) str. 241-247 preuzimanja: 362* citiraj
APA 6th Edition
MITRIKESKI, P.T., ŠIMATOVIĆ, A. i BRČIĆ-KOSTIĆ, K. (2014). Simultaneous plasmid integration: a unifying model of multiple plasmid integration into the yeast chromosome. Periodicum biologorum, 116 (3), 241-247. Preuzeto s https://hrcak.srce.hr/135147
MLA 8th Edition
MITRIKESKI, PETAR T., et al. "Simultaneous plasmid integration: a unifying model of multiple plasmid integration into the yeast chromosome." Periodicum biologorum, vol. 116, br. 3, 2014, str. 241-247. https://hrcak.srce.hr/135147. Citirano 19.11.2019.
Chicago 17th Edition
MITRIKESKI, PETAR T., ANA ŠIMATOVIĆ i KRUNOSLAV BRČIĆ-KOSTIĆ. "Simultaneous plasmid integration: a unifying model of multiple plasmid integration into the yeast chromosome." Periodicum biologorum 116, br. 3 (2014): 241-247. https://hrcak.srce.hr/135147
Harvard
MITRIKESKI, P.T., ŠIMATOVIĆ, A., i BRČIĆ-KOSTIĆ, K. (2014). 'Simultaneous plasmid integration: a unifying model of multiple plasmid integration into the yeast chromosome', Periodicum biologorum, 116(3), str. 241-247. Preuzeto s: https://hrcak.srce.hr/135147 (Datum pristupa: 19.11.2019.)
Vancouver
MITRIKESKI PT, ŠIMATOVIĆ A, BRČIĆ-KOSTIĆ K. Simultaneous plasmid integration: a unifying model of multiple plasmid integration into the yeast chromosome. Periodicum biologorum [Internet]. 2014 [pristupljeno 19.11.2019.];116(3):241-247. Dostupno na: https://hrcak.srce.hr/135147
IEEE
P.T. MITRIKESKI, A. ŠIMATOVIĆ i K. BRČIĆ-KOSTIĆ, "Simultaneous plasmid integration: a unifying model of multiple plasmid integration into the yeast chromosome", Periodicum biologorum, vol.116, br. 3, str. 241-247, 2014. [Online]. Dostupno na: https://hrcak.srce.hr/135147. [Citirano: 19.11.2019.]

Sažetak
Recombination of non-replicative plasmids bearing yeast homology with
the chromosome can integrate the plasmid molecule into the genome. Such process is also known to integrate more than one plasmid molecule leading to multiple, tandem plasmid integration. However, its exact molecular mechanism remains unknown. There are two alternative models to explain such integration. The first predicts single integration of a super-plasmid molecule and the second sequential integration of several independent molecules, but neither is able to comprehend all experimental data. Therefore, here is presented a theoretical model that unifies both prior models owing to the possibility that two plasmid molecules recombine with the chromosome simultaneously. This model was used as a theoretical tool in order to discriminate between existing alternatives extracting the sequential model as a better overall explanation.

Ključne riječi
Saccharomyces; Homologous recombination; Multiple plasmid integration; Genetic model

Hrčak ID: 135147

URI
https://hrcak.srce.hr/135147

Posjeta: 535 *