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Biochemistry and Molecular Biology of Protein Phosphatase 1 in Drosophila melanogaster

Viktor Dombrádi ; Department of Medical Chemistry, University Medical School of Debrecen, H-4026, Debrecen, Hungary

Puni tekst: engleski, pdf (17 MB) str. 569-580 preuzimanja: 130* citiraj
APA 6th Edition
Dombrádi, V. (1995). Biochemistry and Molecular Biology of Protein Phosphatase 1 in Drosophila melanogaster. Croatica Chemica Acta, 68 (3), 569-580. Preuzeto s https://hrcak.srce.hr/136716
MLA 8th Edition
Dombrádi, Viktor. "Biochemistry and Molecular Biology of Protein Phosphatase 1 in Drosophila melanogaster." Croatica Chemica Acta, vol. 68, br. 3, 1995, str. 569-580. https://hrcak.srce.hr/136716. Citirano 07.03.2021.
Chicago 17th Edition
Dombrádi, Viktor. "Biochemistry and Molecular Biology of Protein Phosphatase 1 in Drosophila melanogaster." Croatica Chemica Acta 68, br. 3 (1995): 569-580. https://hrcak.srce.hr/136716
Harvard
Dombrádi, V. (1995). 'Biochemistry and Molecular Biology of Protein Phosphatase 1 in Drosophila melanogaster', Croatica Chemica Acta, 68(3), str. 569-580. Preuzeto s: https://hrcak.srce.hr/136716 (Datum pristupa: 07.03.2021.)
Vancouver
Dombrádi V. Biochemistry and Molecular Biology of Protein Phosphatase 1 in Drosophila melanogaster. Croatica Chemica Acta [Internet]. 1995 [pristupljeno 07.03.2021.];68(3):569-580. Dostupno na: https://hrcak.srce.hr/136716
IEEE
V. Dombrádi, "Biochemistry and Molecular Biology of Protein Phosphatase 1 in Drosophila melanogaster", Croatica Chemica Acta, vol.68, br. 3, str. 569-580, 1995. [Online]. Dostupno na: https://hrcak.srce.hr/136716. [Citirano: 07.03.2021.]

Sažetak
Protein phosphatase 1 (PP1) activity was detected with exogenous and endogenous substrates in Drosophila extract. The catalytic subunit of PP1 was purified to apparent homogeneity. The physicochemical and biochemical properties of the preparation were very similar to those of rabbit PP1. One PP1 catalytic subunit was cloned from a Drosophila cDNA library with the aid of a rabbit PP1 cDNA and oligonucleotide probes. Subsequently, three additional genes encoding for highly similar PP1 isoforms in Drosophila were identified and cloned. It was found that the primary structure of PP1 had been very well conserved during evolution.
One of the isoforms, called PP1(87B), was predominantly expressed during all developmental stages of the insect. Several mutations affecting the PP1(87B) gene were characterized. Based on the phenotype of different mutant alleles, it was concluded that PP1(87B) was involved in viability, mitosis, interphase chromatin condensation and learning. Our results demonstrate that PP1(87B) has several functions which cannot be complemented by other PP1 isoforms of Drosophila.

Hrčak ID: 136716

URI
https://hrcak.srce.hr/136716

Posjeta: 246 *