APA 6th Edition BELEV, B. i ŠIPIĆ, T. (2014). Pathophysiology of hormone-resistant prostate cancer. Periodicum biologorum, 116 (4), 387-392. Preuzeto s https://hrcak.srce.hr/137761
MLA 8th Edition BELEV, BORISLAV i TOMISLAV ŠIPIĆ. "Pathophysiology of hormone-resistant prostate cancer." Periodicum biologorum, vol. 116, br. 4, 2014, str. 387-392. https://hrcak.srce.hr/137761. Citirano 18.05.2021.
Chicago 17th Edition BELEV, BORISLAV i TOMISLAV ŠIPIĆ. "Pathophysiology of hormone-resistant prostate cancer." Periodicum biologorum 116, br. 4 (2014): 387-392. https://hrcak.srce.hr/137761
Harvard BELEV, B., i ŠIPIĆ, T. (2014). 'Pathophysiology of hormone-resistant prostate cancer', Periodicum biologorum, 116(4), str. 387-392. Preuzeto s: https://hrcak.srce.hr/137761 (Datum pristupa: 18.05.2021.)
Vancouver BELEV B, ŠIPIĆ T. Pathophysiology of hormone-resistant prostate cancer. Periodicum biologorum [Internet]. 2014 [pristupljeno 18.05.2021.];116(4):387-392. Dostupno na: https://hrcak.srce.hr/137761
IEEE B. BELEV i T. ŠIPIĆ, "Pathophysiology of hormone-resistant prostate cancer", Periodicum biologorum, vol.116, br. 4, str. 387-392, 2014. [Online]. Dostupno na: https://hrcak.srce.hr/137761. [Citirano: 18.05.2021.]
Sažetak Androgen-deprivation therapy (ADT) has been for many years the cornerstone of metastatic prostate carcinoma (PC) treatment. It is very well documented that the majority of cancer cells in prostate gland remain androgen responsive what was the basis for androgen suppression in treatment. Nevertheless, after some time or sometimes initially, PCa cells become resistant to castration serum level of testosteron, because of some genetic and epigenetic changes that make them independent from hormone activation. There are two therories – the clonal theory and the adaptation theory of how some carcinoma cells become castration-resistant. It has been shown recently, that PCa cells can still use androgen receptor as a major signaling pathway, by activation of enzyme machinery or de novo production of androgen within the cells.