hrcak mascot   Srce   HID

Pregledni rad

Hypoxia in solid tumors: biological responses to hypoxia and implications on therapy and prognosis

NATALIJA DEDIĆ PLAVETIĆ DEDIĆ PLAVETIĆ   ORCID icon orcid.org/0000-0003-0505-4756 ; Department of Oncology, Division of Medical Oncology, University Hospital Center and Zagreb Medical School, Kišpatićeva 12, 10000 Zagreb, Croatia
MARINA BARIĆ1 BARIĆ ; Department of Oncology, Division of Medical Oncology, University Hospital Center and Zagreb Medical School, Zagreb, Croatia
LADA BRADIĆ1 BRADIĆ ; Department of Oncology, Division of Medical Oncology, University Hospital Center and Zagreb Medical School, Zagreb, Croatia
ANA KULIĆ ; Department of Oncology, Division of Pathophysiology and Experimental Oncology, University Hospital Center, Zagreb, Croatia
STJEPKO PLEŠTINA ; Department of Oncology, Division of Medical Oncology, University Hospital Center and Zagreb Medical School, Zagreb, Croatia

Puni tekst: engleski, pdf (713 KB) str. 361-364 preuzimanja: 563* citiraj
APA 6th Edition
DEDIĆ PLAVETIĆ, N.D.P., BARIĆ, M.B., BRADIĆ, L.B., KULIĆ, A. i PLEŠTINA, S. (2014). Hypoxia in solid tumors: biological responses to hypoxia and implications on therapy and prognosis. Periodicum biologorum, 116 (4), 361-364. Preuzeto s https://hrcak.srce.hr/138047
MLA 8th Edition
DEDIĆ PLAVETIĆ, NATALIJA DEDIĆ PLAVETIĆ, et al. "Hypoxia in solid tumors: biological responses to hypoxia and implications on therapy and prognosis." Periodicum biologorum, vol. 116, br. 4, 2014, str. 361-364. https://hrcak.srce.hr/138047. Citirano 13.08.2020.
Chicago 17th Edition
DEDIĆ PLAVETIĆ, NATALIJA DEDIĆ PLAVETIĆ, MARINA BARIĆ1 BARIĆ, LADA BRADIĆ1 BRADIĆ, ANA KULIĆ i STJEPKO PLEŠTINA. "Hypoxia in solid tumors: biological responses to hypoxia and implications on therapy and prognosis." Periodicum biologorum 116, br. 4 (2014): 361-364. https://hrcak.srce.hr/138047
Harvard
DEDIĆ PLAVETIĆ, N.D.P., et al. (2014). 'Hypoxia in solid tumors: biological responses to hypoxia and implications on therapy and prognosis', Periodicum biologorum, 116(4), str. 361-364. Preuzeto s: https://hrcak.srce.hr/138047 (Datum pristupa: 13.08.2020.)
Vancouver
DEDIĆ PLAVETIĆ NDP, BARIĆ MB, BRADIĆ LB, KULIĆ A, PLEŠTINA S. Hypoxia in solid tumors: biological responses to hypoxia and implications on therapy and prognosis. Periodicum biologorum [Internet]. 2014 [pristupljeno 13.08.2020.];116(4):361-364. Dostupno na: https://hrcak.srce.hr/138047
IEEE
N.D.P. DEDIĆ PLAVETIĆ, M.B. BARIĆ, L.B. BRADIĆ, A. KULIĆ i S. PLEŠTINA, "Hypoxia in solid tumors: biological responses to hypoxia and implications on therapy and prognosis", Periodicum biologorum, vol.116, br. 4, str. 361-364, 2014. [Online]. Dostupno na: https://hrcak.srce.hr/138047. [Citirano: 13.08.2020.]

Sažetak
Tumor development, promotion and ability to spread depend greatly on
tumor microenvironment. Rapid growth accompanied by inadequate angiogenesis is the reason why most solid tumors contain hypoxic regions. Activation of hypoxia signaling pathways stimulates neoangiogenesis, alters tumor metabolism, promotes a more aggressive tumor behavior and significantly affects its responsiveness to therapy. Growing amount of evidence suggest that hypoxia induces transcription of tumor promoting genes leading to increased tumor cell proliferation and metastatic potential. Improved understanding of molecular pathways will enable establishment of useful prognostic and predictive factors, along with more effective treatment options.

Ključne riječi
hypoxia; solid tumor; angiogenesis; tumor microenvironment; gene expression; progression; metastasis; resistance to treatment

Hrčak ID: 138047

URI
https://hrcak.srce.hr/138047

Posjeta: 716 *