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https://doi.org/10.5562/cca2551

Spectrophotometric Determination of L-Ascorbic Acid in Pharmaceuticals Based on Its Oxidation by Potassium Peroxymonosulfate and Hydrogen Peroxide

Mirsad Salkić   ORCID icon orcid.org/0000-0002-2540-3784 ; Department of Analytical Chemistry, Faculty of Technology, University of Tuzla, 75000 Tuzla, Bosnia and Herzegovina
Amra Selimović ; Department of Analytical Chemistry, Faculty of Technology, University of Tuzla, 75000 Tuzla, Bosnia and Herzegovina

Puni tekst: engleski, pdf (1 MB) str. 73-79 preuzimanja: 9.401* citiraj
APA 6th Edition
Salkić, M. i Selimović, A. (2015). Spectrophotometric Determination of L-Ascorbic Acid in Pharmaceuticals Based on Its Oxidation by Potassium Peroxymonosulfate and Hydrogen Peroxide. Croatica Chemica Acta, 88 (1), 73-79. https://doi.org/10.5562/cca2551
MLA 8th Edition
Salkić, Mirsad i Amra Selimović. "Spectrophotometric Determination of L-Ascorbic Acid in Pharmaceuticals Based on Its Oxidation by Potassium Peroxymonosulfate and Hydrogen Peroxide." Croatica Chemica Acta, vol. 88, br. 1, 2015, str. 73-79. https://doi.org/10.5562/cca2551. Citirano 04.03.2021.
Chicago 17th Edition
Salkić, Mirsad i Amra Selimović. "Spectrophotometric Determination of L-Ascorbic Acid in Pharmaceuticals Based on Its Oxidation by Potassium Peroxymonosulfate and Hydrogen Peroxide." Croatica Chemica Acta 88, br. 1 (2015): 73-79. https://doi.org/10.5562/cca2551
Harvard
Salkić, M., i Selimović, A. (2015). 'Spectrophotometric Determination of L-Ascorbic Acid in Pharmaceuticals Based on Its Oxidation by Potassium Peroxymonosulfate and Hydrogen Peroxide', Croatica Chemica Acta, 88(1), str. 73-79. https://doi.org/10.5562/cca2551
Vancouver
Salkić M, Selimović A. Spectrophotometric Determination of L-Ascorbic Acid in Pharmaceuticals Based on Its Oxidation by Potassium Peroxymonosulfate and Hydrogen Peroxide. Croatica Chemica Acta [Internet]. 2015 [pristupljeno 04.03.2021.];88(1):73-79. https://doi.org/10.5562/cca2551
IEEE
M. Salkić i A. Selimović, "Spectrophotometric Determination of L-Ascorbic Acid in Pharmaceuticals Based on Its Oxidation by Potassium Peroxymonosulfate and Hydrogen Peroxide", Croatica Chemica Acta, vol.88, br. 1, str. 73-79, 2015. [Online]. https://doi.org/10.5562/cca2551

Sažetak
Two new, accurate, precise, and sensitive spectrophotometric methods were developed for
the assay of L-ascorbic acid in pharmaceutical preparations. The determination of L-ascorbic acid was
based on its oxidation by potassium peroxymonosulfate (method A) and hydrogen peroxide in the
presence of Cu(II) as a catalyst (method B). The molar absorptivities were found to be 1.48×104 and
1.06×104 L mol–1 cm–1 for methods A and B, respectively. Beer's law was obeyed in the concentration
range of 0.65–11.20 μg mL–1 for method A and 0.51–16.00 μg mL–1 for method B. Other compounds
commonly found in vitamin C and multivitamin products did not interfere with the determination of
L-ascorbic acid.. The proposed methods were successfully applied for the determination of L-ascorbic acid
in pharmaceutical formulations. The results obtained with the proposed methods showed good agreement
with those given by the titrimetric method using iodine.

Ključne riječi
L-Ascorbic acid; peroxymonosulfate; hydrogen peroxide; spectrophotometry; pharmaceutical preparations

Hrčak ID: 139132

URI
https://hrcak.srce.hr/139132

Posjeta: 9.676 *