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https://doi.org/10.3325/cmj.2014.55.562

Cardiac allograft vasculopathy: diagnosis, therapy, and prognosis

Boško Skorić   ORCID icon orcid.org/0000-0001-5979-2346 ; Department of Cardiovascular Diseases, University Hospital CenterZagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Maja Čikeš ; Department of Cardiovascular Diseases, University Hospital CenterZagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Jana Ljubas Maček ; Department of Cardiovascular Diseases, University Hospital CenterZagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Željko Baričević ; Department of Cardiovascular Diseases, University Hospital CenterZagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Ivan Škorak ; Department of Cardiovascular Diseases, University Hospital CenterZagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Hrvoje Gašparović ; Department of Cardiac Surgery,University of Zagreb School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia
Bojan Biočina ; Department of Cardiac Surgery,University of Zagreb School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia
Davor Miličić ; Department of Cardiovascular Diseases, University Hospital CenterZagreb, University of Zagreb School of Medicine, Zagreb, Croatia

Puni tekst: engleski, pdf (557 KB) str. 562-576 preuzimanja: 467* citiraj
APA 6th Edition
Skorić, B., Čikeš, M., Ljubas Maček, J., Baričević, Ž., Škorak, I., Gašparović, H., ... Miličić, D. (2014). Cardiac allograft vasculopathy: diagnosis, therapy, and prognosis. Croatian Medical Journal, 55 (6), 562-576. https://doi.org/10.3325/cmj.2014.55.562
MLA 8th Edition
Skorić, Boško, et al. "Cardiac allograft vasculopathy: diagnosis, therapy, and prognosis." Croatian Medical Journal, vol. 55, br. 6, 2014, str. 562-576. https://doi.org/10.3325/cmj.2014.55.562. Citirano 21.10.2021.
Chicago 17th Edition
Skorić, Boško, Maja Čikeš, Jana Ljubas Maček, Željko Baričević, Ivan Škorak, Hrvoje Gašparović, Bojan Biočina i Davor Miličić. "Cardiac allograft vasculopathy: diagnosis, therapy, and prognosis." Croatian Medical Journal 55, br. 6 (2014): 562-576. https://doi.org/10.3325/cmj.2014.55.562
Harvard
Skorić, B., et al. (2014). 'Cardiac allograft vasculopathy: diagnosis, therapy, and prognosis', Croatian Medical Journal, 55(6), str. 562-576. https://doi.org/10.3325/cmj.2014.55.562
Vancouver
Skorić B, Čikeš M, Ljubas Maček J, Baričević Ž, Škorak I, Gašparović H i sur. Cardiac allograft vasculopathy: diagnosis, therapy, and prognosis. Croat Med J. [Internet]. 2014 [pristupljeno 21.10.2021.];55(6):562-576. https://doi.org/10.3325/cmj.2014.55.562
IEEE
B. Skorić, et al., "Cardiac allograft vasculopathy: diagnosis, therapy, and prognosis", Croatian Medical Journal, vol.55, br. 6, str. 562-576, 2014. [Online]. https://doi.org/10.3325/cmj.2014.55.562

Sažetak
Development of cardiac allograft vasculopathy represents
the major determinant of long-term survival in patients after
heart transplantation. Due to graft denervation, these
patients seldom present with classic symptoms of angina
pectoris, and the first clinical presentations are progressive
heart failure or sudden cardiac death. Although coronary
angiography remains the routine technique for coronary
artery disease detection, it is not sensitive enough for
screening purposes. This is especially the case in the first
year after transplantation when diffuse and concentric vascular
changes can be easily detected only by intravascular
ultrasound. The treatment of the established vasculopathy
is disappointing, so the primary effort should be directed
toward early prevention and diagnosis. Due to diffuse vascular
changes, revascularization procedures are restricted
only to a relatively small proportion of patients with favorable
coronary anatomy. Percutaneous coronary intervention
is preferred over surgical revascularization since it leads to
better acute results and patient survival. Although there is
no proven long-term advantage of drug-eluting stents for
the treatment of in-stent restenosis, they are preferred over
bare-metal stents. Severe vasculopathy has a poor prognosis
and the only definitive treatment is retransplantation.
This article reviews the present knowledge on the pathogenesis,
diagnosis, treatment, and prognosis of cardiac allograft
vasculopathy.

Hrčak ID: 139284

URI
https://hrcak.srce.hr/139284

Posjeta: 647 *