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Pregledni rad
https://doi.org/10.11613/BM.2015.017

Aberrant methylation patterns in cancer: a clinical view

Alja Videtic Paska ; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Petra Hudler   ORCID icon orcid.org/0000-0002-2546-0674 ; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

Puni tekst: engleski, pdf (239 KB) str. 161-176 preuzimanja: 372* citiraj
APA 6th Edition
Videtic Paska, A. i Hudler, P. (2015). Aberrant methylation patterns in cancer: a clinical view. Biochemia Medica, 25 (2), 161-176. https://doi.org/10.11613/BM.2015.017
MLA 8th Edition
Videtic Paska, Alja i Petra Hudler. "Aberrant methylation patterns in cancer: a clinical view." Biochemia Medica, vol. 25, br. 2, 2015, str. 161-176. https://doi.org/10.11613/BM.2015.017. Citirano 27.01.2021.
Chicago 17th Edition
Videtic Paska, Alja i Petra Hudler. "Aberrant methylation patterns in cancer: a clinical view." Biochemia Medica 25, br. 2 (2015): 161-176. https://doi.org/10.11613/BM.2015.017
Harvard
Videtic Paska, A., i Hudler, P. (2015). 'Aberrant methylation patterns in cancer: a clinical view', Biochemia Medica, 25(2), str. 161-176. https://doi.org/10.11613/BM.2015.017
Vancouver
Videtic Paska A, Hudler P. Aberrant methylation patterns in cancer: a clinical view. Biochemia Medica [Internet]. 2015 [pristupljeno 27.01.2021.];25(2):161-176. https://doi.org/10.11613/BM.2015.017
IEEE
A. Videtic Paska i P. Hudler, "Aberrant methylation patterns in cancer: a clinical view", Biochemia Medica, vol.25, br. 2, str. 161-176, 2015. [Online]. https://doi.org/10.11613/BM.2015.017

Sažetak
Epigenetic mechanisms, such as DNA methylation, DNA hydroxymethylation, post-translational modifications (PTMs) of histone proteins affecting nucleosome remodelling, and regulation by small and large non-coding RNAs (ncRNAs) work in concert with cis and trans acting elements to drive appropriate gene expression. Advances in detection methods and development of dedicated platforms and methylation arrays resulted in an explosion of information on aberrantly methylated sequences linking deviations in epigenetic landscape with the initiation and progression of complex diseases. Here, we consider how DNA methylation changes in malignancies, such as breast, pancreatic, colorectal, and gastric cancer could be exploited for the purpose of developing specific diagnostic tools. DNA methylation changes can be applicable as biomarkers for detection of malignant disease in easily accessible tissues. Methylation signatures are already proving to be an important marker for determination of drug sensitivity. Even more, promoter methylation patterns of some genes, such as MGMT, SHOX2, and SEPT9, have already been translated into commercial clinical assays aiding in patient assessment as adjunct diagnostic tools. In conclusion, the changes in DNA methylation patterns in tumour cells are slowly gaining entrance into routine diagnostic tests as promising biomarkers and as potential therapeutic targets.

Ključne riječi
biomarkers; CpG islands; DNA methylation; molecular diagnostics; epigenetics

Hrčak ID: 139771

URI
https://hrcak.srce.hr/139771

Posjeta: 663 *