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https://doi.org/10.5562/cca2548

Antibacterial Activity of Pinus pinaster Bark Extract and its Components Against Multidrug-resistant Clinical Isolates of Acinetobacter baumannii

Mirna Ćurković-Perica ; University of Zagreb, Faculty of Science, Department of Biology, Division of Microbiology, Zagreb, Croatia
Jasna Hrenović ; University of Zagreb, Faculty of Science, Department of Biology, Division of Microbiology, Zagreb, Croatia
Nuša Kugler ; Zel-en razvojni center energetike, d.o.o, Sevnica, Slovenia
Ivana Goić-Barišić ; University Hospital Centre Split and University of Split School of Medicine, Department of Clinical Microbiology, Split, Croatia
Mirta Tkalec ; University of Zagreb, Faculty of Science, Department of Biology, Division of Microbiology, Zagreb, Croatia

Puni tekst: engleski, pdf (353 KB) str. 133-137 preuzimanja: 839* citiraj
APA 6th Edition
Ćurković-Perica, M., Hrenović, J., Kugler, N., Goić-Barišić, I. i Tkalec, M. (2015). Antibacterial Activity of Pinus pinaster Bark Extract and its Components Against Multidrug-resistant Clinical Isolates of Acinetobacter baumannii. Croatica Chemica Acta, 88 (2), 133-137. https://doi.org/10.5562/cca2548
MLA 8th Edition
Ćurković-Perica, Mirna, et al. "Antibacterial Activity of Pinus pinaster Bark Extract and its Components Against Multidrug-resistant Clinical Isolates of Acinetobacter baumannii." Croatica Chemica Acta, vol. 88, br. 2, 2015, str. 133-137. https://doi.org/10.5562/cca2548. Citirano 09.04.2020.
Chicago 17th Edition
Ćurković-Perica, Mirna, Jasna Hrenović, Nuša Kugler, Ivana Goić-Barišić i Mirta Tkalec. "Antibacterial Activity of Pinus pinaster Bark Extract and its Components Against Multidrug-resistant Clinical Isolates of Acinetobacter baumannii." Croatica Chemica Acta 88, br. 2 (2015): 133-137. https://doi.org/10.5562/cca2548
Harvard
Ćurković-Perica, M., et al. (2015). 'Antibacterial Activity of Pinus pinaster Bark Extract and its Components Against Multidrug-resistant Clinical Isolates of Acinetobacter baumannii', Croatica Chemica Acta, 88(2), str. 133-137. https://doi.org/10.5562/cca2548
Vancouver
Ćurković-Perica M, Hrenović J, Kugler N, Goić-Barišić I, Tkalec M. Antibacterial Activity of Pinus pinaster Bark Extract and its Components Against Multidrug-resistant Clinical Isolates of Acinetobacter baumannii. Croatica Chemica Acta [Internet]. 2015 [pristupljeno 09.04.2020.];88(2):133-137. https://doi.org/10.5562/cca2548
IEEE
M. Ćurković-Perica, J. Hrenović, N. Kugler, I. Goić-Barišić i M. Tkalec, "Antibacterial Activity of Pinus pinaster Bark Extract and its Components Against Multidrug-resistant Clinical Isolates of Acinetobacter baumannii", Croatica Chemica Acta, vol.88, br. 2, str. 133-137, 2015. [Online]. https://doi.org/10.5562/cca2548

Sažetak
The aim of this research was to test the antibacterial activity of Pinus pinaster aqueous bark extract (PABE) and its basic components against multidrug-resistant isolates of Acinetobacter baumannii belonging to European clone I and II, isolated previously from the clinical outbreaks. The minimum bactericidal concentration of PABE against both clones of A. baumannii was 200 mg ml–1, while lower concentrations showed high antibacterial activity. After 24 h of treatment with 100, 50 or 10 mg ml–1 of extract, the reduction in the number of A. baumannii isolates belonging to European clone I and II was 85.8 ± 2.5 %, 78.5 ± 1.1 %, 66.3 ± 2.5 % and 90.2 ± 1.7 %, 78.6 ± 1.2 %, 69.8 ± 0.7 %, respectively. Several basic components: caffeic acid, catechin, epicatechin, gallic acid and vanillin, detected in the extract by high performance liquid chromatography, contributed to the antibacterial activity of the extract against both clones of A. baumannii. However, the antibacterial activity of extract was higher than that of each tested basic component suggesting that proanthocyanidins, which were present in quite a large amount in the extract, might have also contributed to the activity of the extract. Antibacterial activity of PABE against A. baumannii reveals that complex and inexpensive natural product might be useful in combat against naturally competent bacteria that easily acquire resistance against antibiotics.

Ključne riječi
antimicrobials; aqueous extract; bacteria; multidrug-resistant pathogens; natural compounds

Hrčak ID: 141985

URI
https://hrcak.srce.hr/141985

Posjeta: 1.131 *