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Clinico-pathological Features of Patients with Melanoma and Positive Sentinel Lymph Node Biopsy: A Single Institution Experience

Damir Homolak
Mirna Šitum
Hrvoje Čupić

Puni tekst: engleski, PDF (146 KB) str. 122-122 preuzimanja: 277* citiraj
APA 6th Edition
Homolak, D., Šitum, M. i Čupić, H. (2015). Clinico-pathological Features of Patients with Melanoma and Positive Sentinel Lymph Node Biopsy: A Single Institution Experience. Acta Dermatovenerologica Croatica, 23 (2), 122-122. Preuzeto s https://hrcak.srce.hr/142141
MLA 8th Edition
Homolak, Damir, et al. "Clinico-pathological Features of Patients with Melanoma and Positive Sentinel Lymph Node Biopsy: A Single Institution Experience." Acta Dermatovenerologica Croatica, vol. 23, br. 2, 2015, str. 122-122. https://hrcak.srce.hr/142141. Citirano 17.10.2021.
Chicago 17th Edition
Homolak, Damir, Mirna Šitum i Hrvoje Čupić. "Clinico-pathological Features of Patients with Melanoma and Positive Sentinel Lymph Node Biopsy: A Single Institution Experience." Acta Dermatovenerologica Croatica 23, br. 2 (2015): 122-122. https://hrcak.srce.hr/142141
Harvard
Homolak, D., Šitum, M., i Čupić, H. (2015). 'Clinico-pathological Features of Patients with Melanoma and Positive Sentinel Lymph Node Biopsy: A Single Institution Experience', Acta Dermatovenerologica Croatica, 23(2), str. 122-122. Preuzeto s: https://hrcak.srce.hr/142141 (Datum pristupa: 17.10.2021.)
Vancouver
Homolak D, Šitum M, Čupić H. Clinico-pathological Features of Patients with Melanoma and Positive Sentinel Lymph Node Biopsy: A Single Institution Experience. Acta Dermatovenerol Croat. [Internet]. 2015 [pristupljeno 17.10.2021.];23(2):122-122. Dostupno na: https://hrcak.srce.hr/142141
IEEE
D. Homolak, M. Šitum i H. Čupić, "Clinico-pathological Features of Patients with Melanoma and Positive Sentinel Lymph Node Biopsy: A Single Institution Experience", Acta Dermatovenerologica Croatica, vol.23, br. 2, str. 122-122, 2015. [Online]. Dostupno na: https://hrcak.srce.hr/142141. [Citirano: 17.10.2021.]

Sažetak

ABSTRACT Sentinel lymph node biopsy (SLNB) is an established method for the assessment of tumor aggressiveness in patients with primary cutaneous melanoma (PCM). To improve the criteria for the selection of SLNB candidates, the aim of our study was to determine clinico-pathohistological parameters that can serve as predictors of metastatic progression. We retrospectively evaluated all available clinico-pathohistological parameters in 844 patients with PCM diagnosed between January 1, 2005 and December 31, 2010. SLNB was conducted in 484 (57.3%) patients, 122 (14.5%) of whom had a positive node. The association between predictors and SLNB outcomes (positive SLNB and metastatic development) was tested using logistic regression analysis. The main predictors of positive SLNB were Breslow thickness (adjusted odds ratio (AOR)=1.22; 95% confidence interval (CI)=1.11-1.33), Clark levels (AOR=1.78; 95% CI=1.31-2.40), ulceration (AOR=3.1; 95% CI=1.65-5.81), microsatellitosis, gender, and tumor localization. The predictors of metastatic spread were Breslow thickness (AOR=1,69; 95% CI=1.51-1.89), Clark level (AOR=3.59; 95% CI=2.79-4.62), nodular type of melanoma (AOR=8.21; 95% CI=1.70-39.53), ulceration, mitotic rate, microsatellitosis, gender, and tumor localization. It seems that these parameters should be taken into consideration when selecting patients for SLNB since tumor thickness is not a sufficient predictor of SLNB outcome, particularly in case of very thin lesions.

 

KEY WORDS: primary cutaneous melanoma (PCM); sentinel lymph node biopsy (SLNB); metastases

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Ključne riječi
Primary cutaneous melanoma (PCM); Sentinel lymph node biopsy (SLNB); metastases

Hrčak ID: 142141

URI
https://hrcak.srce.hr/142141

Posjeta: 454 *