Paediatria Croatica, Vol. 58 No. 3, 2014.
Recenzija, Prikaz slučaja
https://doi.org/10.13112/PC.2014.40
Immature colonic ganglion cells as a cause of megacolon in infancy: case report
Danijela Jojkić Pavkov
Melanija Vislavski
Nada Vučković
Bojana Petrovački
Matilda Djolai
Smiljana Marinković
Milena Mitrović
Sažetak
IImmaturity of ganglion cells is a rare form of dysganglionosis that belongs to the group of dysmorphic types, characterized by a
normal or mildly decreased number of ganglion cells, with the cells and their nuclei being considerably smaller in size. The disorder
usually manifests clinically early after birth with abdominal distension, vomiting, feeding intolerance, and delayed passing of meconium.
Diagnostic evaluation may include radiological studies; however, biopsy of colonic mucosa with histochemical analysis is
considered the most reliable method. Manometry is a reliable noninvasive diagnostic study to confi rm motility disorder. Treatment
may be medical in mild cases and more commonly surgical due to complications of the disorder. We present a case of immature
colonic ganglion cells as a cause of megacolon in infancy. In our case, medicamentous treatment was eff ective and led to normalization
of bowel emptying and stool consistency. Considering that follow up rectosigmoidoscopy was refused by the patient’s parents,
we were not able to compare the histopathologic fi ndings before and after the medicamentous treatment; however, the favorable
clinical course made us assume that the ganglion cells had probably fully matured.
Ključne riječi
colon; ganglia; dygestive system abnormalities; megacolon; infant
Hrčak ID:
142305
URI
Datum izdavanja:
25.9.2014.
Posjeta: 2.496 *