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https://doi.org/10.5772/58290

Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug Delivery

Xinyue Huang ; Department of Engineering Science, Oxford University, Oxford, UK
Neil P. Young ; Department of Materials, Oxford University, Oxford, UK
Helen E. Townley ; Department of Engineering Science, Oxford University, Oxford, UK

Puni tekst: engleski, pdf (3 MB) str. 4-2 preuzimanja: 2.997* citiraj
APA 6th Edition
Huang, X., Young, N.P. i Townley, H.E. (2014). Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug Delivery. Nanomaterials and Nanotechnology, 4 (Godište 2014), 4-2. https://doi.org/10.5772/58290
MLA 8th Edition
Huang, Xinyue, et al. "Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug Delivery." Nanomaterials and Nanotechnology, vol. 4, br. Godište 2014, 2014, str. 4-2. https://doi.org/10.5772/58290. Citirano 27.01.2021.
Chicago 17th Edition
Huang, Xinyue, Neil P. Young i Helen E. Townley. "Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug Delivery." Nanomaterials and Nanotechnology 4, br. Godište 2014 (2014): 4-2. https://doi.org/10.5772/58290
Harvard
Huang, X., Young, N.P., i Townley, H.E. (2014). 'Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug Delivery', Nanomaterials and Nanotechnology, 4(Godište 2014), str. 4-2. https://doi.org/10.5772/58290
Vancouver
Huang X, Young NP, Townley HE. Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug Delivery. Nanomaterials and Nanotechnology [Internet]. 2014 [pristupljeno 27.01.2021.];4(Godište 2014):4-2. https://doi.org/10.5772/58290
IEEE
X. Huang, N.P. Young i H.E. Townley, "Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug Delivery", Nanomaterials and Nanotechnology, vol.4, br. Godište 2014, str. 4-2, 2014. [Online]. https://doi.org/10.5772/58290

Sažetak
In this study we have investigated the suitability of a number of different mesoporous silica nanoparticle structures for carrying a drug cargo. We have fully characterized the nanoparticles in terms of their physical parameters; size, surface area, internal pore size and structure. These data are all required if we are to make an informed judgement on the suitability of the structure for drug delivery in vivo. With these parameters in mind, we investigated the loading/unloading profile of a model therapeutic into the pore structure of the nanoparticles. We demonstrate that the release can be controlled by capping the pores on the nanoparticles to achieve temporal control of the unloading. We have also examined the rate and mechanism of the degradation of the nanoparticles over an extended period of time. The eventual dissolution of the nanoparticles after cargo release is a desirable property for a drug delivery system.

Ključne riječi
nanoparticle; silica; mesoporous; morphology; cargo; degradation

Hrčak ID: 142593

URI
https://hrcak.srce.hr/142593

Posjeta: 3.306 *