hrcak mascot   Srce   HID

Izvorni znanstveni članak

Attenuation of systemic inflammatory stress response after preoperative analgesia with clonidine compared to levobupivacaine-a randomised clinical trial

JASMINKA PERSEC   ORCID icon orcid.org/0000-0002-3777-8153 ; Clinic for Anesthesiology, Resuscitation and Intensive Care Medicine, University Hospital Dubrava,Av. G. Šuška 6, 10000 Zagreb, Croatia
MIROSLAV ZUPCIC ; Clinic for Anesthesiology, Resuscitation and Intensive Care Medicine, University Hospital Dubrava, Zagreb, Croatia
ZORAN PERSEC ; Department of Urology, University Hospital Dubrava, Zagreb, Croatia
MARIO KOPLJAR ; Clinical Department of Abdominal Surgery, University Hospital Dubrava, Zagreb, Croatia

Puni tekst: engleski, pdf (1 MB) str. 267-271 preuzimanja: 305* citiraj
APA 6th Edition
PERSEC, J., ZUPCIC, M., PERSEC, Z. i KOPLJAR, M. (2015). Attenuation of systemic inflammatory stress response after preoperative analgesia with clonidine compared to levobupivacaine-a randomised clinical trial. Periodicum biologorum, 117 (2), 267-271. Preuzeto s https://hrcak.srce.hr/142923
MLA 8th Edition
PERSEC, JASMINKA, et al. "Attenuation of systemic inflammatory stress response after preoperative analgesia with clonidine compared to levobupivacaine-a randomised clinical trial." Periodicum biologorum, vol. 117, br. 2, 2015, str. 267-271. https://hrcak.srce.hr/142923. Citirano 16.02.2020.
Chicago 17th Edition
PERSEC, JASMINKA, MIROSLAV ZUPCIC, ZORAN PERSEC i MARIO KOPLJAR. "Attenuation of systemic inflammatory stress response after preoperative analgesia with clonidine compared to levobupivacaine-a randomised clinical trial." Periodicum biologorum 117, br. 2 (2015): 267-271. https://hrcak.srce.hr/142923
Harvard
PERSEC, J., et al. (2015). 'Attenuation of systemic inflammatory stress response after preoperative analgesia with clonidine compared to levobupivacaine-a randomised clinical trial', Periodicum biologorum, 117(2), str. 267-271. Preuzeto s: https://hrcak.srce.hr/142923 (Datum pristupa: 16.02.2020.)
Vancouver
PERSEC J, ZUPCIC M, PERSEC Z, KOPLJAR M. Attenuation of systemic inflammatory stress response after preoperative analgesia with clonidine compared to levobupivacaine-a randomised clinical trial. Periodicum biologorum [Internet]. 2015 [pristupljeno 16.02.2020.];117(2):267-271. Dostupno na: https://hrcak.srce.hr/142923
IEEE
J. PERSEC, M. ZUPCIC, Z. PERSEC i M. KOPLJAR, "Attenuation of systemic inflammatory stress response after preoperative analgesia with clonidine compared to levobupivacaine-a randomised clinical trial", Periodicum biologorum, vol.117, br. 2, str. 267-271, 2015. [Online]. Dostupno na: https://hrcak.srce.hr/142923. [Citirano: 16.02.2020.]

Sažetak
Background and purpose: Use of analgetics before the pain stimulus
(preventive analgesia) obstruct development of neuroplastic changes in central nervous system, and reduces pain. Furthermore, preventive analgesia can block harmful central nervous system response and inflammation as an early consequence of operation as well. Investigation hypothesis is that preoperative central clonidine will reduce systemic inflammatory stress response better than levobupivacaine.

Materials and methods:. Patients were allocated to three groups, according
to preoperative epidural use of 5 μg/kg clonidine (n=17), 0.25%
levobupivacaine (n=12) or saline as control group (n=13). Before operation, 1 h after the beginning, 1 h, 6 h, 12 h and 24 h after the operation following parameters were analyzed: procalcitonin (PCT), interleukine-6 (IL-6), C-reactive protein (CRP) and lactate.

Results: There were no significant differences between groups in age,
gender, body mass index and operation time. We demonstrated significant
reduction in PCT, IL-6, CRP and lactate levels in preoperative clonidine
group, compared to preoperative levobupivacaine group and controle group.

Conclusion. These results support importance of clonidine central effect on
pain pathways and systemic inflammatory stress response blockade.

Ključne riječi
clonidine; levobupivacaine; preoperative analgesia; systemic inflammatory stress response; epidural analgesia

Hrčak ID: 142923

URI
https://hrcak.srce.hr/142923

Posjeta: 458 *