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The acute effect of the antioxidant drug "U-74389G" on mean corpuscular hemoglobin levels during hypoxia reoxygenation injury in rats

Constantinos Tsompos ; Mesologi County Hospital, Department of obstetrics & gynecology, Etolakarnania, Greece
Constantinos Panoulis ; Aretaieion Hospital, Department of obstetrics & gynecology, Athens University, Atiiki, Greece
Konstantinos Toutouzas ; Ipokrateion General Hospital, Department of surgery, Athens University, Atiiki Greece
George Zografos ; Ipokrateion General Hospital, Department of surgery, Athens University, Atiiki Greece
Apostolos Papalois ; Experimental research center ELPEN Pharmaceuticals, S.A.Inc., Co.

Puni tekst: engleski, pdf (374 KB) str. 17-24 preuzimanja: 191* citiraj
APA 6th Edition
Tsompos, C., Panoulis, C., Toutouzas, K., Zografos, G. i Papalois, A. (2015). The acute effect of the antioxidant drug "U-74389G" on mean corpuscular hemoglobin levels during hypoxia reoxygenation injury in rats. Medica Jadertina, 45 (1-2), 17-24. Preuzeto s https://hrcak.srce.hr/143624
MLA 8th Edition
Tsompos, Constantinos, et al. "The acute effect of the antioxidant drug "U-74389G" on mean corpuscular hemoglobin levels during hypoxia reoxygenation injury in rats." Medica Jadertina, vol. 45, br. 1-2, 2015, str. 17-24. https://hrcak.srce.hr/143624. Citirano 04.07.2020.
Chicago 17th Edition
Tsompos, Constantinos, Constantinos Panoulis, Konstantinos Toutouzas, George Zografos i Apostolos Papalois. "The acute effect of the antioxidant drug "U-74389G" on mean corpuscular hemoglobin levels during hypoxia reoxygenation injury in rats." Medica Jadertina 45, br. 1-2 (2015): 17-24. https://hrcak.srce.hr/143624
Harvard
Tsompos, C., et al. (2015). 'The acute effect of the antioxidant drug "U-74389G" on mean corpuscular hemoglobin levels during hypoxia reoxygenation injury in rats', Medica Jadertina, 45(1-2), str. 17-24. Preuzeto s: https://hrcak.srce.hr/143624 (Datum pristupa: 04.07.2020.)
Vancouver
Tsompos C, Panoulis C, Toutouzas K, Zografos G, Papalois A. The acute effect of the antioxidant drug "U-74389G" on mean corpuscular hemoglobin levels during hypoxia reoxygenation injury in rats. Medica Jadertina [Internet]. 2015 [pristupljeno 04.07.2020.];45(1-2):17-24. Dostupno na: https://hrcak.srce.hr/143624
IEEE
C. Tsompos, C. Panoulis, K. Toutouzas, G. Zografos i A. Papalois, "The acute effect of the antioxidant drug "U-74389G" on mean corpuscular hemoglobin levels during hypoxia reoxygenation injury in rats", Medica Jadertina, vol.45, br. 1-2, str. 17-24, 2015. [Online]. Dostupno na: https://hrcak.srce.hr/143624. [Citirano: 04.07.2020.]

Sažetak
Aim: The aim of this experimental study was to examine the effect of the antioxidant drug “U-74389G”, on rat model and particularly in a hypoxia – reoxygenation protocol. The beneficial effect or non-effectiveness of that molecule was studied hematologically using blood mean corpuscular hemoglobin (MCH) levels.
Methods: 40 rats of mean weight 231.875 gr were used in the study. MCH levels were measured 60 min after reperfusion (groups A and C) and 120 min after reperfusion (groups B and D) with the administration of drug U-74389G in groups C and D.
Results: The results were that U-74389G administration significantly increased the MCH levels by 2.40% ± 0.57% (p = 0.0001). Reoxygenation time non-significantly decreased the MCH levels by 0.48% ± 0.69 (p = 0.4103). However, U-74389G administration and reoxygenation time together significantly increased the MCH levels by 1.33% ± 0.36% (p = 0.0005).
Conclusion: The results of this study indicate that U-74389G administration either alone or interacted with reoxygenation time has significant increasing short – term effects on the pathophysiology recovery of MCH values.

Ključne riječi
hypoxia, U-74389G; meann corpuscular hemoglobin levels; reperfusion

Hrčak ID: 143624

URI
https://hrcak.srce.hr/143624

[hrvatski]

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