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Arhiv za higijenu rada i toksikologiju, Vol. 46 No. 4, 1995.

Izvorni znanstveni članak

Trimethyl lead neurotoxicity in the rat: changes in glial fibrillary acidic protein (GFAP)

Zdaolong Gong ; Nelson Institute of Environmental Medicine, New York University Medical Center, Tuxedo, NY, U.S.A.
AR Little Jr. ; Nelson Institute of Environmental Medicine, New York University Medical Center, Tuxedo, NY, U.S.A.
Han El-Fawal ; Nelson Institute of Environmental Medicine, New York University Medical Center, Tuxedo, NY, U.S.A.
Hugh L. Evans ; Nelson Institute of Environmental Medicine, New York University Medical Center, Tuxedo, NY, U.S.A.

Puni tekst: engleski, pdf (7 MB) str. 381-389 preuzimanja: 129* citiraj
APA 6th Edition
Gong, Z., Little Jr., A., El-Fawal, H. i Evans, H.L. (1995). Trimethyl lead neurotoxicity in the rat: changes in glial fibrillary acidic protein (GFAP). Arhiv za higijenu rada i toksikologiju, 46 (4), 381-389. Preuzeto s https://hrcak.srce.hr/145200
MLA 8th Edition
Gong, Zdaolong, et al. "Trimethyl lead neurotoxicity in the rat: changes in glial fibrillary acidic protein (GFAP)." Arhiv za higijenu rada i toksikologiju, vol. 46, br. 4, 1995, str. 381-389. https://hrcak.srce.hr/145200. Citirano 20.05.2019.
Chicago 17th Edition
Gong, Zdaolong, AR Little Jr., Han El-Fawal i Hugh L. Evans. "Trimethyl lead neurotoxicity in the rat: changes in glial fibrillary acidic protein (GFAP)." Arhiv za higijenu rada i toksikologiju 46, br. 4 (1995): 381-389. https://hrcak.srce.hr/145200
Harvard
Gong, Z., et al. (1995). 'Trimethyl lead neurotoxicity in the rat: changes in glial fibrillary acidic protein (GFAP)', Arhiv za higijenu rada i toksikologiju, 46(4), str. 381-389. Preuzeto s: https://hrcak.srce.hr/145200 (Datum pristupa: 20.05.2019.)
Vancouver
Gong Z, Little Jr. A, El-Fawal H, Evans HL. Trimethyl lead neurotoxicity in the rat: changes in glial fibrillary acidic protein (GFAP). Arh Hig Rada Toksikol. [Internet]. 1995 [pristupljeno 20.05.2019.];46(4):381-389. Dostupno na: https://hrcak.srce.hr/145200
IEEE
Z. Gong, A. Little Jr., H. El-Fawal i H.L. Evans, "Trimethyl lead neurotoxicity in the rat: changes in glial fibrillary acidic protein (GFAP)", Arhiv za higijenu rada i toksikologiju, vol.46, br. 4, str. 381-389, 1995. [Online]. Dostupno na: https://hrcak.srce.hr/145200. [Citirano: 20.05.2019.]

Sažetak
The literature on the toxicology of lead provides little evidence of the neurotoxicity of organic lead compounds. Toxicant-induced changes in the concentration of glial fibrillary acidic protein (GFAP) in the brain may help clarify at which stage of neurotoxicity astrocytes are affected and whether GFAP may provide an index of toxicity. Male F344 rats (>42 days old) were exposed to 0 (control), 8 or 16 ppm lead as trimethyl lead (TMPb) in drinking water for up to 14 days. Weight gain was significantly reduced in both exposed groups. Control rats had the expected brain regional pattern of GFAP concentration with the highest in the hippocampus and cerebellum and lowest in the cerebral cortex. The hippocampus was the region very sensitive to TMPb, with increased GFAP in rats exposed to 8 and 16 ppm TMPb for 14 days. There was a significant time-response in rats exposed to 8 ppm TMPb with decreases in GFAP on day 7 and increases on day 14. A hypothesis concerning this biphasic change in GFAP concentrations is discussed. The results indicate that GFAP may be used to indicate the role of the astrocyte in the neurotoxicity of TMPb. GFAP concentration, as biomarker of TMPb effect, was as sensitive to TMPb as body weight and thus may provide a marker of neurotoxicity.

Ključne riječi
astrocytes; body weight; brain; water consumption

Hrčak ID: 145200

URI
https://hrcak.srce.hr/145200

[hrvatski]

Posjeta: 220 *