hrcak mascot   Srce   HID

Acta Pharmaceutica, Vol. 66 No. 1, 2016.

Izvorni znanstveni članak
https://doi.org/10.1515/acph-2016-0002

Design and statistical optimization of effervescent floating drug delivery system of theophylline using response surface methodology

VENKATA SRIKANTH MEKA ; School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia
CHEW EE LI ; School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia
RAVI SHESHALA ; School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia

Puni tekst: engleski, pdf (737 KB) str. 35-51 preuzimanja: 409* citiraj
APA 6th Edition
MEKA, V.S., LI, C.E. i SHESHALA, R. (2016). Design and statistical optimization of effervescent floating drug delivery system of theophylline using response surface methodology. Acta Pharmaceutica, 66 (1), 35-51. https://doi.org/10.1515/acph-2016-0002
MLA 8th Edition
MEKA, VENKATA SRIKANTH, et al. "Design and statistical optimization of effervescent floating drug delivery system of theophylline using response surface methodology." Acta Pharmaceutica, vol. 66, br. 1, 2016, str. 35-51. https://doi.org/10.1515/acph-2016-0002. Citirano 24.02.2019.
Chicago 17th Edition
MEKA, VENKATA SRIKANTH, CHEW EE LI i RAVI SHESHALA. "Design and statistical optimization of effervescent floating drug delivery system of theophylline using response surface methodology." Acta Pharmaceutica 66, br. 1 (2016): 35-51. https://doi.org/10.1515/acph-2016-0002
Harvard
MEKA, V.S., LI, C.E., i SHESHALA, R. (2016). 'Design and statistical optimization of effervescent floating drug delivery system of theophylline using response surface methodology', Acta Pharmaceutica, 66(1), str. 35-51. doi: https://doi.org/10.1515/acph-2016-0002
Vancouver
MEKA VS, LI CE, SHESHALA R. Design and statistical optimization of effervescent floating drug delivery system of theophylline using response surface methodology. Acta Pharm. [Internet]. 2016 [pristupljeno 24.02.2019.];66(1):35-51. doi: https://doi.org/10.1515/acph-2016-0002
IEEE
V.S. MEKA, C.E. LI i R. SHESHALA, "Design and statistical optimization of effervescent floating drug delivery system of theophylline using response surface methodology", Acta Pharmaceutica, vol.66, br. 1, str. 35-51, 2016. [Online]. doi: https://doi.org/10.1515/acph-2016-0002

Sažetak
The aim of this research was to formulate effervescent floating drug delivery systems of theophylline, using different release retarding polymers such as ethyl cellulose, Eudragit® L100, xanthan gum and polyethylene oxide (PEO) N12K. Sodium bicarbonate was used as a gas generating agent. Direct compression was used to formulate floating tablets and the tablets were evaluated for their physicochemical and dissolution characteristics. PEO based formulations produced better drug release properties than other formulations. Hence, it was further optimized by central composite design. Further subjects of research were the effect of formulation variables on floating lag time and the percentage of drug released at the seventh hour (D7h). The optimum quantities of PEO and sodium bicarbonate, which had the highest desirability close to 1.0, were chosen as the statistically optimized formulation. No interaction was found between theophylline and PEO by Fourier Transformation Infrared spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) studies.

Ključne riječi
theophylline; gastroretentive; floating; central composite; PEO N12K

Hrčak ID: 145269

URI
https://hrcak.srce.hr/145269

Posjeta: 548 *