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Acta Pharmaceutica, Vol. 66 No. 1, 2016.

Kratko priopćenje
https://doi.org/10.1515/acph-2016-0010

Biphasic dissolution method for quality control and assurance of drugs containing active substances in the form of weak acid salts

ALEŠ FRANC ; Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
JAN MUSELÍK ; Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic; Masaryk Memorial Cancer Institute, Brno, Czech Republic
ROMAN GONĚC ; Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
DAVID VETCHÝ ; Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic

Puni tekst: engleski, pdf (343 KB) str. 139-145 preuzimanja: 514* citiraj
APA 6th Edition
FRANC, A., MUSELÍK, J., GONĚC, R. i VETCHÝ, D. (2016). Biphasic dissolution method for quality control and assurance of drugs containing active substances in the form of weak acid salts. Acta Pharmaceutica, 66 (1), 139-145. https://doi.org/10.1515/acph-2016-0010
MLA 8th Edition
FRANC, ALEŠ, et al. "Biphasic dissolution method for quality control and assurance of drugs containing active substances in the form of weak acid salts." Acta Pharmaceutica, vol. 66, br. 1, 2016, str. 139-145. https://doi.org/10.1515/acph-2016-0010. Citirano 22.05.2019.
Chicago 17th Edition
FRANC, ALEŠ, JAN MUSELÍK, ROMAN GONĚC i DAVID VETCHÝ. "Biphasic dissolution method for quality control and assurance of drugs containing active substances in the form of weak acid salts." Acta Pharmaceutica 66, br. 1 (2016): 139-145. https://doi.org/10.1515/acph-2016-0010
Harvard
FRANC, A., et al. (2016). 'Biphasic dissolution method for quality control and assurance of drugs containing active substances in the form of weak acid salts', Acta Pharmaceutica, 66(1), str. 139-145. doi: https://doi.org/10.1515/acph-2016-0010
Vancouver
FRANC A, MUSELÍK J, GONĚC R, VETCHÝ D. Biphasic dissolution method for quality control and assurance of drugs containing active substances in the form of weak acid salts. Acta Pharm. [Internet]. 2016 [pristupljeno 22.05.2019.];66(1):139-145. doi: https://doi.org/10.1515/acph-2016-0010
IEEE
A. FRANC, J. MUSELÍK, R. GONĚC i D. VETCHÝ, "Biphasic dissolution method for quality control and assurance of drugs containing active substances in the form of weak acid salts", Acta Pharmaceutica, vol.66, br. 1, str. 139-145, 2016. [Online]. doi: https://doi.org/10.1515/acph-2016-0010

Sažetak
Substances in the form of weak acid salts have been found to be problematic for dissolution testing. Their absorption can start only after they are turned into the form of an acid following the gastric passage although they were administered in the form of a salt. Due to poor solubility, they cannot be tested in acidic gastric environment for a biased dissolution profile. The biphasic dissolution method is promising for overcoming this obstacle. Tablets with warfarin clathrate sodium salt in two concentrations and two different particle size distributions were tested as a suitable model for finding the medium and process conditions of dissolution. The dissolution method based on the use of the upper organic layer (1-octanol) and the lower aqueous layer (0.1 mol L–1 HCl) was found suitable and discriminatory for tablets containing active substances in the form of salts of weak acids. The method also reflects physical differences in the quality of used substances.

Ključne riječi
salts of weak acids; warfarin sodium; dissolution method

Hrčak ID: 146067

URI
https://hrcak.srce.hr/146067

Posjeta: 650 *