Acta clinica Croatica, Vol. 45 No. 3, 2006.
Ostalo
Acquired Factor V Inhibitor: A Case Report
Petar Gaćina
Rajko Kušec
Dubravka Čaržavec
Biserka Raić
Vladimir Stančić
Sažetak
A 19-year-old asymptomatic man who was admitted to our hospital for investigation of prolonged screening coagulation assays, prothrombin time and activated partial thromboplastin time is presented. Further evaluation revealed factor V deficiency and the presence of specific factor V inhibitors. The appearance of these inhibitors may be associated with administration of some antibiotics, topical bovine thrombin preparations containing bovine factor V during surgical or dental procedures, after blood transfusions and in patients with malignancy or autoimmune diseases. Factor V inhibitors may also develop spontaneously in patients without any clearly identifiable cause. Our patient had no personal or family history of bleeding tendency or thromboembolic event. There is a general consensus that asymptomatic patients should not be treated regardless of their inhibitor titer and residual factor V levels.
Ključne riječi
Blood coagulation factors - antagonists and inhibitors; Antibodies - immunology; Blood coagulation disorders - immunology; Factor V - immunology; Factor V - adverse effects; Case report
Hrčak ID:
14063
URI
Datum izdavanja:
1.9.2006.
Posjeta: 1.329 *