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https://doi.org/10.15255/CABEQ.2014.2092

Synthesis and Characterization of β-Cyclodextrin/alginate Nanoparticle as a Novel Drug Delivery System

T.-D. Nguyen   ORCID icon orcid.org/0000-0001-6330-8916 ; a)Department of Pharmaceutical Chemistry Technology, Institute of Chemical Technology, Vietnam Academy of Science and Technology, 1 Mac Dinh Chi Street, District 1, Ho Chi Minh City, Vietnam; b)Department of Chemistry, Konkuk University, 1 Hwayang-dong, G
T. Hong-Ngan Tran ; Department of Pharmaceutical Chemistry Technology, Institute of Chemical Technology, Vietnam Academy of Science and Technology, 1 Mac Dinh Chi Street, District 1, Ho Chi Minh City, Vietnam
C.-H. Nguyen ; Department of Pharmaceutical Chemistry Technology, Institute of Chemical Technology, Vietnam Academy of Science and Technology, 1 Mac Dinh Chi Street, District 1, Ho Chi Minh City, Vietnam
C. Im ; Department of Chemistry, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143–701, South Korea
C.-H. Dang ; Department of Pharmaceutical Chemistry Technology, Institute of Chemical Technology, Vietnam Academy of Science and Technology, 1 Mac Dinh Chi Street, District 1, Ho Chi Minh City, Vietnam

Puni tekst: engleski, pdf (1 MB) str. 429-435 preuzimanja: 567* citiraj
APA 6th Edition
Nguyen, T.-., Hong-Ngan Tran, T., Nguyen, C.-., Im, C. i Dang, C.-. (2015). Synthesis and Characterization of β-Cyclodextrin/alginate Nanoparticle as a Novel Drug Delivery System. Chemical and Biochemical Engineering Quarterly, 29 (3), 429-435. https://doi.org/10.15255/CABEQ.2014.2092
MLA 8th Edition
Nguyen, T.-D., et al. "Synthesis and Characterization of β-Cyclodextrin/alginate Nanoparticle as a Novel Drug Delivery System." Chemical and Biochemical Engineering Quarterly, vol. 29, br. 3, 2015, str. 429-435. https://doi.org/10.15255/CABEQ.2014.2092. Citirano 14.11.2019.
Chicago 17th Edition
Nguyen, T.-D., T. Hong-Ngan Tran, C.-H. Nguyen, C. Im i C.-H. Dang. "Synthesis and Characterization of β-Cyclodextrin/alginate Nanoparticle as a Novel Drug Delivery System." Chemical and Biochemical Engineering Quarterly 29, br. 3 (2015): 429-435. https://doi.org/10.15255/CABEQ.2014.2092
Harvard
Nguyen, T.-., et al. (2015). 'Synthesis and Characterization of β-Cyclodextrin/alginate Nanoparticle as a Novel Drug Delivery System', Chemical and Biochemical Engineering Quarterly, 29(3), str. 429-435. https://doi.org/10.15255/CABEQ.2014.2092
Vancouver
Nguyen T-, Hong-Ngan Tran T, Nguyen C-, Im C, Dang C-. Synthesis and Characterization of β-Cyclodextrin/alginate Nanoparticle as a Novel Drug Delivery System. Chemical and Biochemical Engineering Quarterly [Internet]. 2015 [pristupljeno 14.11.2019.];29(3):429-435. https://doi.org/10.15255/CABEQ.2014.2092
IEEE
T.-. Nguyen, T. Hong-Ngan Tran, C.-. Nguyen, C. Im i C.-. Dang, "Synthesis and Characterization of β-Cyclodextrin/alginate Nanoparticle as a Novel Drug Delivery System", Chemical and Biochemical Engineering Quarterly, vol.29, br. 3, str. 429-435, 2015. [Online]. https://doi.org/10.15255/CABEQ.2014.2092

Sažetak
The aim of this work was to study a novel nanoparticle system formed from alginate and β-cyclodextrin by ionotropic gelation method and to evaluate their potential for the association and delivery of drugs. The nanoparticles were prepared by electrostatic interactions between Ca2+/alginate gel and β-cyclodextrin. Morphology and structure characterization of nanoparticles was investigated by scanning electron micrographs (SEM), transmission electron microscope (TEM), Fourier transform infrared spectra (FTIR). The nanoparticle size was about 50 – 80 nm and their structure quite regular and consistent.
Ketoprofen, chosen as a model drug, was incorporated into the nanocarriers with association efficiency of 50.7 % and loading efficiency of 5.7 %. Ketoprofen released from the nanoparticles was 57 % at pH 7.4 and 69 % at pH 5.0 for 4 h.

Ključne riječi
nanoparticle; nanocarrier; drug delivery; β-cyclodextrin; alginate; ketoprofen; drug release

Hrčak ID: 147008

URI
https://hrcak.srce.hr/147008

Posjeta: 763 *