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The therapeutic agents that target ATP-sensitive potassium channels
HUSSEIN N. RUBAIY
; School of Medicine, The Leeds Institute of Cardiovascular and Metabolic Medicine, LIGHT Building 7.27, University of Leeds, U.K.
Puni tekst: engleski, pdf (504 KB)
APA 6th Edition
RUBAIY, H.N. (2016). The therapeutic agents that target ATP-sensitive potassium channels. Acta Pharmaceutica, 66 (1), 23-34. https://doi.org/10.1515/acph-2016-0006
MLA 8th Edition
RUBAIY, HUSSEIN N.. "The therapeutic agents that target ATP-sensitive potassium channels." Acta Pharmaceutica, vol. 66, br. 1, 2016, str. 23-34. https://doi.org/10.1515/acph-2016-0006. Citirano 15.02.2019.
Chicago 17th Edition
RUBAIY, HUSSEIN N.. "The therapeutic agents that target ATP-sensitive potassium channels." Acta Pharmaceutica 66, br. 1 (2016): 23-34. https://doi.org/10.1515/acph-2016-0006
RUBAIY, H.N. (2016). 'The therapeutic agents that target ATP-sensitive potassium channels', Acta Pharmaceutica, 66(1), str. 23-34. doi: https://doi.org/10.1515/acph-2016-0006
RUBAIY HN. The therapeutic agents that target ATP-sensitive potassium channels. Acta Pharm. [Internet]. 2016 [pristupljeno 15.02.2019.];66(1):23-34. doi: https://doi.org/10.1515/acph-2016-0006
H.N. RUBAIY, "The therapeutic agents that target ATP-sensitive potassium channels", Acta Pharmaceutica, vol.66, br. 1, str. 23-34, 2016. [Online]. doi: https://doi.org/10.1515/acph-2016-0006
ATP-sensitive potassium (KATP) channels are a major drug target for the treatment of type-2 diabetes. KATP channels are ubiquitously expressed and link the metabolic state to electrical excitability. In pancreatic β-cells, KATP channels are crucial in the regulation of glucose-induced insulin secretion. Also, KATP channels are involved in the protection against neuronal seizures and ischaemic stress in the heart, brain and in the regulation of vascular smooth muscle tone. Functional KATP channels are hetero-octamers composed of two subunits, a pore forming Kir6, which is a member of the inwardly rectifying potassium channels family, and a regulatory sulphonylurea receptor (SUR). In response to nucleotides and pharmaceutical agonists and antagonists, SUR allosterically regulates channel gating. The allosteric communication pathways between these two heterologus proteins in KATP channels are still poorly understood. This review will highlight the therapeutic agents that target KATP channels and are used to treat diabetes and cardiovascular diseases.
ATP-sensitive potassium channels; therapeutic agents; diabetes; cardiovascular; inwardly rectifying potassium channels; sulphonylurea receptor
Hrčak ID: 147080
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