Ostalo
Relationship Between Serum Fetuin-A Levels and Carotid Intima-media Thickness in Turkish Patients with Mild to Moderate Psoriasis. A Case-control Study
Belkız Uyar
; Sifa University, Faculty of Medicine, Department of Dermatology,,
Muhittin Akyıldız
; Sifa University, Faculty of Medicine, Department of Biochemistry,
Aynur Solak
; Sifa University, Faculty of Medicine, Department of Radiology
Berhan Genç
; Sifa University, Faculty of Medicine, Department of Radiology
Ali Saklamaz
; Sifa University, Faculty of Medicine, Department of Endocrinology
Sažetak
Previous studies have associated severe psoriasis and psoriatic arthritis with an increased risk of atherosclerosis. However, the association between patients with mild-to-moderate plaque-type psoriasis and atherosclerosis has yet to be studied in depth.This study investigates a) possible correlations between carotid intima-media thickness (CIMT) and serum fetuin-A levels in patients with mild-to-moderate psoriasis and b) correlations between psoriasis severity index (PASI) and fetuin-A levels. The latter correlation was recently reported to be important for wound healing and vascular calcification. In this prospective study, a total of 70 patients with mild-to-moderate psoriasis and 66 control participants were included. PASI, CIMT, and serum fetuin-A levels were examined in all patients. Although the difference in fetuin-A values was not statistically significant between patients with mild-to-moderate plaque-type psoriasis and control groups (P=0.401), the CIMT levels in the psoriasis group were significantly higher than the control group (P=0.002). There were no correlations among fetuin-A levels, CIMT, and PASI. This study establishes an association between mild to moderate psoriasis and atherosclerosis. This study also concludes that, similarly to patients with severe psoriasis, CIMT levels are a better indicator of cardiovascular risk than serum fetuin-A levels in patients diagnosed with mild-to-moderate plaque-type psoriasis.
Ključne riječi
cardiovascular disease; fetuin-A; psoriasis; carotid intima-media thickness; psoriasis area and severity index
Hrčak ID:
147140
URI
Datum izdavanja:
16.10.2015.
Posjeta: 860 *