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Acta Pharmaceutica, Vol. 66 No. 2, 2016.

Izvorni znanstveni članak
https://doi.org/10.1515/acph-2016-0012

The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via spray freeze drying process

NARGES POURSINA ; Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
ALIREZA VATANARA1 ; Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
MOHAMMAD REZA ROUINI1 ; Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
KAMBIZ GILANI1 ; Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
ABDOLHOSSEIN ROUHOLAMINI NAJAFABADI1 ; Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Puni tekst: engleski, pdf (1 MB) str. 207-218 preuzimanja: 301* citiraj
APA 6th Edition
POURSINA, N., VATANARA1, A., ROUINI1, M.R., GILANI1, K. i NAJAFABADI1, A.R. (2016). The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via spray freeze drying process. Acta Pharmaceutica, 66 (2), 207-218. https://doi.org/10.1515/acph-2016-0012
MLA 8th Edition
POURSINA, NARGES, et al. "The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via spray freeze drying process." Acta Pharmaceutica, vol. 66, br. 2, 2016, str. 207-218. https://doi.org/10.1515/acph-2016-0012. Citirano 21.02.2019.
Chicago 17th Edition
POURSINA, NARGES, ALIREZA VATANARA1, MOHAMMAD REZA ROUINI1, KAMBIZ GILANI1 i ABDOLHOSSEIN ROUHOLAMINI NAJAFABADI1. "The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via spray freeze drying process." Acta Pharmaceutica 66, br. 2 (2016): 207-218. https://doi.org/10.1515/acph-2016-0012
Harvard
POURSINA, N., et al. (2016). 'The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via spray freeze drying process', Acta Pharmaceutica, 66(2), str. 207-218. doi: https://doi.org/10.1515/acph-2016-0012
Vancouver
POURSINA N, VATANARA1 A, ROUINI1 MR, GILANI1 K, NAJAFABADI1 AR. The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via spray freeze drying process. Acta Pharm. [Internet]. 2016 [pristupljeno 21.02.2019.];66(2):207-218. doi: https://doi.org/10.1515/acph-2016-0012
IEEE
N. POURSINA, A. VATANARA1, M.R. ROUINI1, K. GILANI1 i A.R. NAJAFABADI1, "The effect of excipients on the stability and aerosol performance of salmon calcitonin dry powder inhalers prepared via spray freeze drying process", Acta Pharmaceutica, vol.66, br. 2, str. 207-218, 2016. [Online]. doi: https://doi.org/10.1515/acph-2016-0012

Sažetak
Spray freeze drying was developed to produce dry powders suitable for applications such as inhalation delivery. In the current study, the spray freeze drying technique was employed to produce inhalable salmon calcitonin microparticles. Effects of the carrier type, concentration of hydroxyl propyl-β-cyclodextrin and the presence of Tween 80 on the chemical and structural stability, as well as on the aerosol performance of the particles were investigated. The results indicated that hydroxyl propyl-β-cyclodextrin had the most important effect on the chemical stability of the powder and strongly increased its stability by increasing its concentration in the formulation. Chemically stable formulations (over 90 % recovery) were selected for further examinations. Fluorescence spectroscopy and circular dichroism suggested that the formulations were structurally stable. Aerosol performance showed that the Tween-free powders produced higher fine particle fraction values than the formulations containing Tween (53.7 vs. 41.92 % for trehalose content and 52.85 vs. 43.06 % for maltose content).

Ključne riječi
salmon calcitonin; inhalation; spray freeze drying; hydroxypropyl-β-cyclodextrin; fine particle fraction; stability

Hrčak ID: 147310

URI
https://hrcak.srce.hr/147310

Posjeta: 459 *