Izvorni znanstveni članak
Use of Serum Levels of Proinflfl ammatory Cytokine IL-1a in Chronic Hepatitis C
Nenad Vanis
; University of Sarajevo, Refferal Centre for Gastrointestinal Endoscopy, University Clinical Center Sarajevo, Department of Gastroenterology and Hepatology, Sarajevo, Bosnia and Herzegovina
Amila Mehmedović
; University of Sarajevo, Refferal Centre for Gastrointestinal Endoscopy, University Clinical Center Sarajevo, Department of Gastroenterology and Hepatology, Sarajevo, Bosnia and Herzegovina
Rusmir Mesihović
; University of Sarajevo, Refferal Centre for Gastrointestinal Endoscopy, University Clinical Center Sarajevo, Department of Gastroenterology and Hepatology, Sarajevo, Bosnia and Herzegovina
Sažetak
Immunoregulatory cytokines infl uence the persistence of hepatitis C virus chronic infection and the extent of liver damage.
Interleukin-1 plays an important role in the infl ammatory process. Some studies have demonstrated that IL-1 production
was impaired in patients with chronic infections of hepatitis C virus, implying that IL-1 may play a role in viral
clearance. In this study, along with routine laboratory tests, has been performed the analysis of serum levels of proinfl ammatory
cytokine IL-1a in order of better understanding and monitoring of chronic hepatitis C. The aim of study was to
analyze the usefulness of laboratory tests, which are routinely used in the assessment of liver disease with specifi ed immunological
parameters, in patients with chronic hepatitis C. Total of 60 subjects were divided into two groups: HCV- PCR
positive and negative group. The control group of 30 healthy participans was included. Apart from standard laboratory
tests, the analysis included serum levels of cytokine IL-1 a. IL-1a had the highest mean concentration in group of viral
hepatitis C, with PCR positive test (5.73 pg / mL), and then in of chronic viral hepatitis C, PCR negative test (5.39 pg / mL).
ANOVA test proves that IL-1a in the healthy group was different from other groups as follows: in relation to HCV- RNAPCR
positive patients statistical signifi cance level was p<0.001 (F=32 755); in relation to HCV- RNA- PCR negative
was also statistically signifi cant at p <0.001 (F=182 361); Cytokine IL-1 was statistically analyzed separately and compared
by group 1 and 2 using Student t-test for independent samples. Statistical signifi cance was observed at p=0.026.
IL-1 a was positively correlated with the duration of the illness (p<0.01) and with serum ALT activity (p<0.01) and serum
AST activity (p<0.01). Using multivariate analysis model »Factor Analysis«, was made signifi cant stratifi cation predictive
parameters in relation to the cytokine IL-1a, stratifi ed signifi cance is indicated as follows: 1. Age, 2. history of receiving
transfusions, 3. ALT, 4. AST, 5. MELD score (negative), 6. Child-Pugh score (negative). IL-1a was signifi cantly elevated
in infl ammatory conditions of pronounced activity (PCR positive hepatitis). IL-1a may have important role as
marker of both infl ammation and hepatic injury, particularly in the course of hepatitis C. Results suggest that infl ammatory
and immune parameters, analyzed together can signifi cantly contribute to the understanding and predicting of
chronic liver damage.
Ključne riječi
chronic hepatitis C; parameters of infl ammation; IL- 1a
Hrčak ID:
147692
URI
Datum izdavanja:
30.3.2015.
Posjeta: 611 *