Izvorni znanstveni članak

The relationship between bone mineral density and lipid status and anthropometric parameters in patients with dyslipidaemia

Olga Cvijanović ; Zavod za anatomiju, Medicinski fakultet Sveučilišta u Rijeci
Željka Crnčević Orlić ; Katedra za internu medicinu, Medicinski fakultet Sveučilišta u Rijeci, Rijeka - Odjel za endokrinologiju, dijabetes i bolesti metabolizma, KBC Rijeka, Rijeka
Nenad Bićanić ; Katedra za internu medicinu, Medicinski fakultet Sveučilišta u Rijeci, Rijeka - Odjel za endokrinologiju, dijabetes i bolesti metabolizma, KBC Rijeka, Rijeka
Maja Ivaniš ; Katedra za internu medicinu, Medicinski fakultet Sveučilišta u Rijeci, Rijeka - Odjel za endokrinologiju, dijabetes i bolesti metabolizma, KBC Rijeka, Rijeka
Luka Đudarić ; Zavod za anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Ivana Dolušić ; Zavod za anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Sanja Zoričič Cvek ; Zavod za anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Dragica Bobinac ; Zavod za anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka

Sažetak

Aim: Statins significantly reduce the risk of cardiovascular diseases, and with regardto the mechanism of action similar to bisphosphonates, may have a favorable effect on bonemetabolism. The aim was to investigate the relationship between bone mineral densities(BMD) of the lumbar spine and left hip with anthropometric and lipid parameters in patientstreated for dyslipidemia. In addition, the aim was to analyze the relationship between theperiod of treatment with statins and BMD. Patients and methods: Respondents were mostlypostmenopausal women (N = 65), and men (N = 15) who are treated with statins for dyslipidemia.Patients who are treated for osteoporosis with bisphosphonates were excluded from thestudy group. Bone densitometry was used to measure values of BMD of the lumbar spine andleft hip in all patients. Results: BMD of the lumbar spine is correlated positively with concentrationof triglycerides in the blood (r = 0.24, P = 0.046), but negatively correlated with totalcholesterol (r = -0.31, P = 0.008), HDL cholesterol (r = -0.28, P = 0.020) and LDL cholesterol(r = -0.35, P = 0.004). Left hip BMD correlated positively with triglycerides (r = 0.25, P = 0.031),whereas a negative correlation was found with total cholesterol (r = -0.30, P = 0.011), HDLcholesterol (r = -0.28, P = 0.015) and LDL cholesterol (r = -0.30, P = 0.010). Period of treatmentwith statins is positively correlated with BMD in the lumbar spine (r = 0.23, P = 0.048).Conclusion: It is obvious that there is a relationship between bone metabolism and lipid profile,as well as between bone metabolism and the period of treatment with statins. However, it is necessaryto carry out new randomized clinical researches to fully clarify these relationships.

Ključne riječi

bone remodeling; cholesterol; dyslipidemia; statins

Hrčak ID:

148298

URI

https://hrcak.srce.hr/148298

Datum izdavanja:

1.12.2015.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.701 *