Acta clinica Croatica, Vol. 44 No. 3, 2005.
Izvorni znanstveni članak
Detection of Chromosome 1 Deletion by FISH on Ependymoma Touch Imprints Suggests a Region out of Chromosome 22 as Important for Tumor Relapse
Demetrio Tamiolakis
Nikolas Papadopoulos
John Venizelos
Maria Lambropoulou
Sylva Nikolaidou
Sophia Bolioti
Artemis Kiziridou
George Alexiadis
Constantine Simopoulos
Sažetak
Ependymomas are glial tumors. They constitute approximately 5%-10% of intracranial tumors. Ependymomas are tumors which can recur. Predictive factors of outcome in ependymomas are not well established. Karyotypic studies are relatively scarce and loss of chromosome 22 has been described to correlate with recurrence. We are unaware of any reports involving chromosome 1 aberrations in the malignant progression of ependymomas. Cytogenetic analysis of 4 ependymomas was performed using double-target fluorescent in situ hybridization (FISH) and focusing on chromosomes 1 and 22. One patient had recurrent tumor. FISH was performed on 500 nuclei/tumors. All four cases showed a loss of chromosome 22q, while only one showed an additional loss of chromosome 1p, and it was the one with tumor relapse. We support the presence of tumor suppressor gene on 1p associated with relapse in ependymomas and suggest that the chromosome 1p status by FISH may identify a high risk group of patients harboring this tumor. Additional studies in this direction are needed, as our results refer to a minimal number of individuals analyzed.
Ključne riječi
Brain neoplasms - genetics; Ependymoma - genetics; Ependymoma - pathology; Chromosomes - human - pair 1; Chromosomes - human - pair 22
Hrčak ID:
14263
URI
Datum izdavanja:
1.9.2005.
Posjeta: 1.956 *