Acta clinica Croatica, Vol. 44 No. 4, 2005.
Ostalo
Panhypopituitarism in a 45-Year-Old Woman: Case Report
Martina Matovinović
Andreja Marić
Velena Radošević
Milan Vrkljan
Križo Katinić
Vladimir Kalousek
Miljenko Kalousek
Sažetak
A case of a 45-year-old woman with untreated panhypopituitarism is presented. Hypopituitarism is a rare disorder consisting of multiple deficiencies of hormones originating from the adenohypophysis. It is divided into primary and secondary. Primary disorders manifest at the pituitary level, whereas secondary hypopituitarism implies hypothalamic affection. Partial or total loss of all pituitary hormones is called panhypopituitarism. Hypopituitarism can be slow and insidious or severe and life-threatening. The expression of symptoms largely depends on the patient's age and the hormones involved. The leading symptom is growth retardation when the disorder develops in childhood or puberty. Sometimes years may elapse without accurate diagnosis, as in the case described. To date, only a few cases of untreated hypopituitarism have been published. In our patient, clinical examination revealed short stature and weak osteomuscular constitution, primary amenorrhea and lack of development of secondary sex characteristics. The patient's clinical history revealed signs of hypopituitarism from childhood, which had been untreated until she presented to our clinic. The results of complete testing showed the lack of all pituitary hormones and antidiuretic hormone, which was consistent with panhypopituitarism, including central diabetes insipidus.
Ključne riječi
Hypopituitarism - etiology; Hypopituitarism - diagnosis; Pituitary gland - abnormalities; Growth; Case report
Hrčak ID:
14299
URI
Datum izdavanja:
1.12.2005.
Posjeta: 3.138 *