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Effect of Octreotide on Growth Hormone Secretion in Patients with Acromegaly

Branka Vizner
Milan Vrkljan
Mladen Sekso
Maja Berković
Josip Rešetić
Miljenko Kalousek

Puni tekst: engleski, pdf (132 KB) str. 175-178 preuzimanja: 655* citiraj
APA 6th Edition
Vizner, B., Vrkljan, M., Sekso, M., Berković, M., Rešetić, J. i Kalousek, M. (2001). Effect of Octreotide on Growth Hormone Secretion in Patients with Acromegaly. Acta clinica Croatica, 40 (3), 175-178. Preuzeto s https://hrcak.srce.hr/14865
MLA 8th Edition
Vizner, Branka, et al. "Effect of Octreotide on Growth Hormone Secretion in Patients with Acromegaly." Acta clinica Croatica, vol. 40, br. 3, 2001, str. 175-178. https://hrcak.srce.hr/14865. Citirano 12.11.2019.
Chicago 17th Edition
Vizner, Branka, Milan Vrkljan, Mladen Sekso, Maja Berković, Josip Rešetić i Miljenko Kalousek. "Effect of Octreotide on Growth Hormone Secretion in Patients with Acromegaly." Acta clinica Croatica 40, br. 3 (2001): 175-178. https://hrcak.srce.hr/14865
Harvard
Vizner, B., et al. (2001). 'Effect of Octreotide on Growth Hormone Secretion in Patients with Acromegaly', Acta clinica Croatica, 40(3), str. 175-178. Preuzeto s: https://hrcak.srce.hr/14865 (Datum pristupa: 12.11.2019.)
Vancouver
Vizner B, Vrkljan M, Sekso M, Berković M, Rešetić J, Kalousek M. Effect of Octreotide on Growth Hormone Secretion in Patients with Acromegaly. Acta clinica Croatica [Internet]. 2001 [pristupljeno 12.11.2019.];40(3):175-178. Dostupno na: https://hrcak.srce.hr/14865
IEEE
B. Vizner, M. Vrkljan, M. Sekso, M. Berković, J. Rešetić i M. Kalousek, "Effect of Octreotide on Growth Hormone Secretion in Patients with Acromegaly", Acta clinica Croatica, vol.40, br. 3, str. 175-178, 2001. [Online]. Dostupno na: https://hrcak.srce.hr/14865. [Citirano: 12.11.2019.]

Sažetak
A majority of growth hormone secreting pituitary adenomas respond well to somatostatin and somatostatin analogues. The acute action of octreotide, a synthetic somatostatin analogue, on growth hormone secretion was assessed in 42 patients with clinically and laboratory verified acromegaly. Octreotide was administered subcutaneously in a dose of 50 mg. Blood sampling was performed at 1-hour intervals during 6 hours of testing. The mean basal values of growth hormone (c±SE) was 26.3±4.5 ng/ml (range 6.1-66.6 ng/ml), and of IGF-I 2940±171.7 IU/l (range 2350-4856 IU/l). Reduction in growth hormone values below 5 ng/ml was recorded in 31 (73.8%), suppression by more than 50% in 5 (11.9%) and by more than 45% in 3 (7.1%) patients. Maximal suppression was noticed in the first two hours of testing. In 3 (7.1%) patients, resistance to octreotide with no change in growth hormone values was observed. In conclusion, octreotide reduces growth hormone values in most acromegalic patients. A small proportion of acromegalic patients do not respond well to octreotide, probably due to the lack of somatostatin receptors on tumor cells. We consider the acute octreotide test as a very useful tool in triage of acromegalic patients eligible for medicamentous treatment.

Ključne riječi
Acromegaly, drug therapy; Octreotide, therapeutic use; Octreotide, pharmacology

Hrčak ID: 14865

URI
https://hrcak.srce.hr/14865

[hrvatski]

Posjeta: 1.124 *