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Acta Pharmaceutica, Vol. 66 No. 2, 2016.

Izvorni znanstveni članak
https://doi.org/10.1515/acph-2016-0025

Piecewise function parameters as responses of the design of experiment in development of a pulsatile release chronopharmaceutical system

ANDREEA LOREDANA VONICA-GLIGOR ; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy “Iuliu Haţieganu”, 40012 Cluj-Napoca, Romania; S.C. Polisno Pharmaceuticals S.R.L., 550201 Sibiu, Romania; Faculty of Medicine, “Lucian Blaga
IOAN TOMUŢĂ   ORCID icon orcid.org/0000-0002-5094-008X ; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy “Iuliu Haţieganu”, 40012 Cluj-Napoca, Romania
SORIN E. LEUCUŢA ; Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Medicine and Pharmacy “Iuliu Haţieganu”, 40012 Cluj-Napoca, Romania

Puni tekst: engleski, pdf (1 MB) str. 173-189 preuzimanja: 178* citiraj
APA 6th Edition
VONICA-GLIGOR, A.L., TOMUŢĂ, I. i LEUCUŢA, S.E. (2016). Piecewise function parameters as responses of the design of experiment in development of a pulsatile release chronopharmaceutical system. Acta Pharmaceutica, 66 (2), 173-189. https://doi.org/10.1515/acph-2016-0025
MLA 8th Edition
VONICA-GLIGOR, ANDREEA LOREDANA, et al. "Piecewise function parameters as responses of the design of experiment in development of a pulsatile release chronopharmaceutical system." Acta Pharmaceutica, vol. 66, br. 2, 2016, str. 173-189. https://doi.org/10.1515/acph-2016-0025. Citirano 18.02.2019.
Chicago 17th Edition
VONICA-GLIGOR, ANDREEA LOREDANA, IOAN TOMUŢĂ i SORIN E. LEUCUŢA. "Piecewise function parameters as responses of the design of experiment in development of a pulsatile release chronopharmaceutical system." Acta Pharmaceutica 66, br. 2 (2016): 173-189. https://doi.org/10.1515/acph-2016-0025
Harvard
VONICA-GLIGOR, A.L., TOMUŢĂ, I., i LEUCUŢA, S.E. (2016). 'Piecewise function parameters as responses of the design of experiment in development of a pulsatile release chronopharmaceutical system', Acta Pharmaceutica, 66(2), str. 173-189. doi: https://doi.org/10.1515/acph-2016-0025
Vancouver
VONICA-GLIGOR AL, TOMUŢĂ I, LEUCUŢA SE. Piecewise function parameters as responses of the design of experiment in development of a pulsatile release chronopharmaceutical system. Acta Pharm. [Internet]. 2016 [pristupljeno 18.02.2019.];66(2):173-189. doi: https://doi.org/10.1515/acph-2016-0025
IEEE
A.L. VONICA-GLIGOR, I. TOMUŢĂ i S.E. LEUCUŢA, "Piecewise function parameters as responses of the design of experiment in development of a pulsatile release chronopharmaceutical system", Acta Pharmaceutica, vol.66, br. 2, str. 173-189, 2016. [Online]. doi: https://doi.org/10.1515/acph-2016-0025

Sažetak
The aim of this work was to develop a pulsatile release system with metoprolol for chronotherapeutical use by coating swellable mini-tablets with Eudragit RS. To study the influence of the formulation factors (amount of coating polymer, plasticizer percentage in film coating and swelling agent percentage in mini-tablets), a Box-Behnken design of experiment (DoE) was used. To evaluate the influence of the studied factors on the sigmoid shape of the dissolution profile, piecewise function parameters were used as the responses of DoE. The results show that higher concentrations of coating polymer and higher concentrations of plasticizer polymer led to a thicker and more elastic polymeric film, which led to a delay in drug release. Using the parameters of the piecewise function as DoE responses, an optimum formulation with a sigmoid shape dissolution profile and a 2.5-h lag time followed by rapid drug release were obtained.

Ključne riječi
pulsatile release; chronopharmaceutical system; piecewise function; design of experiment; Eudragit RS; metoprolol

Hrčak ID: 153865

URI
https://hrcak.srce.hr/153865

Posjeta: 289 *