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https://doi.org/10.1515/aiht-2016-67-2708

Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study

Damir Sirovina ; Department of Biology, Division of Zoology, Faculty of Science, University of Zagreb, Zagreb, Croatia
Nada Oršolić ; Department of Biology, Division of Animal Physiology, Faculty of Science, University of Zagreb, Zagreb, Croatia
Marijana Zovko Končić ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Gordana Gregorović ; Department of Biology, Division of Zoology, Faculty of Science, University of Zagreb, Zagreb, Croatia

Puni tekst: engleski, pdf (1 MB) str. 19-24 preuzimanja: 624* citiraj
APA 6th Edition
Sirovina, D., Oršolić, N., Zovko Končić, M. i Gregorović, G. (2016). Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study. Arhiv za higijenu rada i toksikologiju, 67 (1), 19-24. https://doi.org/10.1515/aiht-2016-67-2708
MLA 8th Edition
Sirovina, Damir, et al. "Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study." Arhiv za higijenu rada i toksikologiju, vol. 67, br. 1, 2016, str. 19-24. https://doi.org/10.1515/aiht-2016-67-2708. Citirano 19.04.2021.
Chicago 17th Edition
Sirovina, Damir, Nada Oršolić, Marijana Zovko Končić i Gordana Gregorović. "Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study." Arhiv za higijenu rada i toksikologiju 67, br. 1 (2016): 19-24. https://doi.org/10.1515/aiht-2016-67-2708
Harvard
Sirovina, D., et al. (2016). 'Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study', Arhiv za higijenu rada i toksikologiju, 67(1), str. 19-24. https://doi.org/10.1515/aiht-2016-67-2708
Vancouver
Sirovina D, Oršolić N, Zovko Končić M, Gregorović G. Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study. Arh Hig Rada Toksikol. [Internet]. 2016 [pristupljeno 19.04.2021.];67(1):19-24. https://doi.org/10.1515/aiht-2016-67-2708
IEEE
D. Sirovina, N. Oršolić, M. Zovko Končić i G. Gregorović, "Naringenin ameliorates pathological changes in liver and kidney of diabetic mice: a preliminary study", Arhiv za higijenu rada i toksikologiju, vol.67, br. 1, str. 19-24, 2016. [Online]. https://doi.org/10.1515/aiht-2016-67-2708

Sažetak
The effect of naringenin, a flavonoid found in grapefruit, orange, and tomato, on lipid peroxidation and histopathological changes in the liver and kidneys of alloxan-induced diabetic mice were investigated. Two days after alloxan injection (75 mg kg-1, i.v.), naringenin ethanolic solution (0.5 % v/v) was given to mice intraperitoneally (50 mg kg-1 per day) for seven days. Naringenin’s impact on lipid peroxidation was measured by the 2-thiobarbituric acid test and histopathological changes were examined under a light microscope. Naringenin administration resulted in a significant decrease of lipid peroxidation level in liver and kidney tissue, as well as in a decreased number of vacuolated liver cells and degree of vacuolisation. Indications of tissue repair in kidney suggested that amelioration of diabetes-induced renal damage could be achieved over a longer period of time. Findings suggest that naringenin could be considered a dietary supplement in the prevention or treatment of diabetic complications and other diseases connected wih oxidative stress, and gives a hope that it could show similar effects in the treatment of diabetes in humans.

Ključne riječi
diabetes; diabetic kidney; histopathology; lipid peroxidation; liver disease; naringenin

Hrčak ID: 154583

URI
https://hrcak.srce.hr/154583

[hrvatski]

Posjeta: 958 *