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Acta Pharmaceutica, Vol.66 No.3 Rujan 2016.

Kratko priopćenje
https://doi.org/10.1515/acph-2016-0034

A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride

JITKA MUŽÍKOVÁ ; Department of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic
ALENA KUBÍČKOVÁ ; Department of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic

Puni tekst: engleski, pdf (636 KB) str. 433-441 preuzimanja: 154* citiraj
APA
MUŽÍKOVÁ, J., KUBÍČKOVÁ, A. (2016). A study of compressibility and compactibility of directly compressible tableting materials containing tramadol hydrochloride. Acta Pharmaceutica, 66(3). doi:10.1515/acph-2016-0034

Sažetak
The paper evaluates and compares the compressibility and compactibility of directly compressible tableting materials for the preparation of hydrophilic gel matrix tablets containing tramadol hydrochloride and the coprocessed dry binders Prosolv® SMCC 90 and Disintequik™ MCC 25. The selected types of hypromellose are Methocel™ Premium K4M and Methocel™ Premium K100M in the concentrations of 30 and 50 % concentrations, the lubricant being magnesium stearate in a 1 % concentration. Compressibility is evaluated by means of the energy profile of compression process and compactibility by the tensile strength of tablets.
The values of total energy of compression and plasticity were higher in the tableting materials containing Prosolv® SMCC 90 than in those containing Disintequik™ MCC 25. Tramadol slightly decreased the values of total energy of compression and plasticity. Tableting materials containing Prosolv® SMCC 90 yielded stronger tablets. Tramadol decreased the strength of tablets from both coprocessed dry binders.

Ključne riječi
tramadol hydrochloride; hydrophilic matrix tablets; coprocessed dry binder; hypromellose; energy profile of compression; tensile strength of tablets

Hrčak ID: 154686

URI
https://hrcak.srce.hr/154686

Posjeta: 233 *