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Acta clinica Croatica, Vol. 54. No. 4., 2015.

Izvorni znanstveni članak

Effects of three-week zinc and melatonin supplementation on the oxidant-antioxidant system in experimental renal ischemia-reperfusion in rats

Mine Yilmaz ; Selcuk University, Medical School, Department of Physiology, Konya, Turkey
Rasim Mogulkoc   ORCID icon orcid.org/0000-0001-6155-6780 ; Selcuk University, Medical School, Department of Physiology, Konya, Turkey
Abdulkerim Kasim Baltaci ; Selcuk University, Medical School, Department of Physiology, Konya, Turkey

Puni tekst: engleski, pdf (130 KB) str. 395-401 preuzimanja: 326* citiraj
APA 6th Edition
Yilmaz, M., Mogulkoc, R. i Baltaci, A.K. (2015). Effects of three-week zinc and melatonin supplementation on the oxidant-antioxidant system in experimental renal ischemia-reperfusion in rats. Acta clinica Croatica, 54. (4.), 395-401. Preuzeto s https://hrcak.srce.hr/154804
MLA 8th Edition
Yilmaz, Mine, et al. "Effects of three-week zinc and melatonin supplementation on the oxidant-antioxidant system in experimental renal ischemia-reperfusion in rats." Acta clinica Croatica, vol. 54., br. 4., 2015, str. 395-401. https://hrcak.srce.hr/154804. Citirano 21.02.2019.
Chicago 17th Edition
Yilmaz, Mine, Rasim Mogulkoc i Abdulkerim Kasim Baltaci. "Effects of three-week zinc and melatonin supplementation on the oxidant-antioxidant system in experimental renal ischemia-reperfusion in rats." Acta clinica Croatica 54., br. 4. (2015): 395-401. https://hrcak.srce.hr/154804
Harvard
Yilmaz, M., Mogulkoc, R., i Baltaci, A.K. (2015). 'Effects of three-week zinc and melatonin supplementation on the oxidant-antioxidant system in experimental renal ischemia-reperfusion in rats', Acta clinica Croatica, 54.(4.), str. 395-401. Preuzeto s: https://hrcak.srce.hr/154804 (Datum pristupa: 21.02.2019.)
Vancouver
Yilmaz M, Mogulkoc R, Baltaci AK. Effects of three-week zinc and melatonin supplementation on the oxidant-antioxidant system in experimental renal ischemia-reperfusion in rats. Acta clinica Croatica [Internet]. 2015 [pristupljeno 21.02.2019.];54.(4.):395-401. Dostupno na: https://hrcak.srce.hr/154804
IEEE
M. Yilmaz, R. Mogulkoc i A.K. Baltaci, "Effects of three-week zinc and melatonin supplementation on the oxidant-antioxidant system in experimental renal ischemia-reperfusion in rats", Acta clinica Croatica, vol.54., br. 4., str. 395-401, 2015. [Online]. Dostupno na: https://hrcak.srce.hr/154804. [Citirano: 21.02.2019.]

Sažetak
Renal ischemia-reperfusion directly affects glomerular and tubular epithelium. Oxygen free radicals have a significant part in the pathophysiology of renal ischemia-reperfusion injury. The present study aimed to identify the effects of 3-week zinc, melatonin, and zinc + melatonin supplementation on malondialdehyde (MDA) levels in tissue and plasma and glutathione levels (GSH) in erythrocytes and tissue of rats with experimentally induced renal ischemia-reperfusion injury. The study included Wistar albino rats with a mean weight of 250 g. Study groups were formed as follows: control, sham-control, ischemia + reperfusion, zinc + ischemia-reperfusion, melatonin + ischemia-reperfusion, and zinc + melatonin + ischemia-reperfusion. Animals were supplemented with zinc and melatonin 3 mg/kg/day i.p. for 3 weeks before the induction of ischemia-reperfusion. Renal ischemia-reperfusion was induced in the left kidney under general anesthesia and consisted of ischemia for 45 minutes and reperfusion for 1 hour. After the procedure, animals were sacrificed and blood and kidney samples were collected to analyze MDA and GSH levels. GSH values in kidney tissues and erythrocytes were found to be elevated in the groups supplemented with zinc and melatonin (p<0.005). When MDA values in renal tissue and plasma were examined, it was seen that ischemia significantly elevated this parameter, while zinc and melatonin supplementation significantly inhibited MDA values (p<0.002). The results of the study indicated that oxidative injury of the blood and renal tissues of rats increased in association with ischemia-reperfusion, but zinc and melatonin supplementation before ischemia-reperfusion markedly reduced this oxidative damage.

Ključne riječi
Acute kidney injury – prevention and control; Reperfusion injury – prevention and control; Zinc – therapeutic use; Melatonin – therapeutic use; Free radicals; Rats

Hrčak ID: 154804

URI
https://hrcak.srce.hr/154804

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