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Acta clinica Croatica, Vol. 54. No. 4., 2015.

Izvorni znanstveni članak

Migraine, carotid stiffness and genetic polymorphism

Vanja Bašić-Kes ; University Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Miljenka-Jelena Jurašić   ORCID icon orcid.org/0000-0002-1199-6013 ; University Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Iris Zavoreo   ORCID icon orcid.org/0000-0001-9358-1665 ; University Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Lejla Ćorić ; University Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Krešimir Rotim ; University Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; University Department of Neurosurgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia

Puni tekst: engleski, pdf (141 KB) str. 409-415 preuzimanja: 203* citiraj
APA 6th Edition
Bašić-Kes, V., Jurašić, M., Zavoreo, I., Ćorić, L. i Rotim, K. (2015). Migraine, carotid stiffness and genetic polymorphism. Acta clinica Croatica, 54. (4.), 409-415. Preuzeto s https://hrcak.srce.hr/154828
MLA 8th Edition
Bašić-Kes, Vanja, et al. "Migraine, carotid stiffness and genetic polymorphism." Acta clinica Croatica, vol. 54., br. 4., 2015, str. 409-415. https://hrcak.srce.hr/154828. Citirano 22.05.2019.
Chicago 17th Edition
Bašić-Kes, Vanja, Miljenka-Jelena Jurašić, Iris Zavoreo, Lejla Ćorić i Krešimir Rotim. "Migraine, carotid stiffness and genetic polymorphism." Acta clinica Croatica 54., br. 4. (2015): 409-415. https://hrcak.srce.hr/154828
Harvard
Bašić-Kes, V., et al. (2015). 'Migraine, carotid stiffness and genetic polymorphism', Acta clinica Croatica, 54.(4.), str. 409-415. Preuzeto s: https://hrcak.srce.hr/154828 (Datum pristupa: 22.05.2019.)
Vancouver
Bašić-Kes V, Jurašić M, Zavoreo I, Ćorić L, Rotim K. Migraine, carotid stiffness and genetic polymorphism. Acta clinica Croatica [Internet]. 2015 [pristupljeno 22.05.2019.];54.(4.):409-415. Dostupno na: https://hrcak.srce.hr/154828
IEEE
V. Bašić-Kes, M. Jurašić, I. Zavoreo, L. Ćorić i K. Rotim, "Migraine, carotid stiffness and genetic polymorphism", Acta clinica Croatica, vol.54., br. 4., str. 409-415, 2015. [Online]. Dostupno na: https://hrcak.srce.hr/154828. [Citirano: 22.05.2019.]

Sažetak
Recently migraine has been associated with increased arterial stiffness, procoagulant state, increased incidence of cerebral white matter lesions (WML) and stroke. Our aim was to compare the characteristics of migraineurs to headache free controls regarding their functional carotid ultrasound parameters. Sixty patients (45 women) with migraine (mean age 40.42±10.61 years) were compared with 45 controls (30 women) with no prior history of repeating headache (men age 38.94±5.46 years) using E-tracking software on Alpha 10 ultrasound platform. Student’s t-test was used on statistical analysis with alpha <0.05. All tested carotid vascular parameters were worse in patients with migraine including increased intima-media thickness, greater carotid diameter and carotid diameter change, as well as several arterial stiffness indices. Additionally, patients with migraine had greater incidence of homozygous mutations for procoagulant genes (MTHFR (C677T), PAI-1 and ACE I/D) than expected. Computed tomography and magnetic resonance imaging of the brain showed WML in 11 patients, four of them migraine with aura patients. Since we established increased carotid stiffness and higher frequency of procoagulant gene mutations in migraineurs, we propose prospective ultrasound monitoring in such patients, especially those with detected WML, in order to timely commence more active and specific preventive stroke management strategies.

Ključne riječi
Migraine disorders; Carotid artery diseases; Vascular stiffness; Atherosclerosis; Stroke

Hrčak ID: 154828

URI
https://hrcak.srce.hr/154828

[hrvatski]

Posjeta: 395 *