Izvorni znanstveni članak
The Effect of Amiodarone on the Cornea
Mia Zorić-Geber
Boris Starčević
Ivanka Petric
Renata Iveković
Zdravko Mandić
Sažetak
The most common side-effect of the anti-arrhythmic amiodarone is keratopathy. The goal of this study was to assess the frequency of this side-effect in our population of cardiology patients treated with amiodarone. We also wanted to assess the consequences on eye sight. The study was conducted as collaboration between the divisions of ophthalmology and cardiology of Sestre milosrdnice University Hospital, Zagreb and it included patients receiving amiodarone for longer than 6 months (100-800 mg/ day). Changes on the cornea were objectively evaluated using a biomicroscope and have been classified into three stages. Clinical changes on the cornea have been observed in 92% of the patients. Changes in eye sight were not observed. Amiodarone keratopathy is related to dosage and duration of treatment. This keratopathy progresses even with reduced dosage; however, complete regression occurs once administration of medication is discontinued. Taking this study into account, as well as the available published data, we are of the opinion that amiodarone therapy should not be discontinued due to changes in the eye-sight and if the amiodarone therapy is of critical importance to the welfare of the patient.
Ključne riječi
Amiodarone keratopathy; corneal microdeposits
Hrčak ID:
15005
URI
Datum izdavanja:
1.11.2002.
Posjeta: 1.715 *