Izvorni znanstveni članak

https://doi.org/10.20471/acc.2016.55.01.2

Vertebral Osteomyelitis in Adult Patients – Characteristics and Outcome

Matej Mustapić ; Department of Diagnostic and Interventional Radiology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Klaudija Višković ; Department of Radiology and Ultrasound, Dr Fran Mihaljević University Hospital for Infectious Diseases, Zagreb, Croatia
Igor Borić ; Department of Radiology, Sveta Katarina Special Hospital, Zabok, Croatia
Domagoj Marjan ; Department of Diagnostic and Interventional Radiology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Dijana Zadravec ; Department of Diagnostic and Interventional Radiology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Josip Begovac ; Dr Fran Mihaljević Univesity Hospital for Infectious Diseases, Zagreb, Croatia

Sažetak

The aim of the study was to assess disease characteristics and outcome in patients with vertebral osteomyelitis (VO). A two medical centre retrospective cohort study was performed by chart review after discharge of 110 patients with confirmed VO treated during a 5-year period. Patients were divided in two groups: patients with uncomplicated VO and patients with complicated VO. All patients underwent clinical and biological examinations and magnetic resonance imaging (MRI) according to the same protocol. Patients with complicated VO were significantly older (p=0.038). They were longer treated with antibiotics parenterally (p=0.047) and more often
surgically (p<0.001). In these patients, high Charlson comorbidity index (CCI) score was more often observed (p=0.024), as well as liver cirrhosis (p=0.013) and degenerative spine disease (p=0.007) as
comorbidities. Patients with advanced MRI changes of VO had a modified CCI score of 2 or more (p=0.006). They more often experienced neurological deficit (p=0.021). Staphylococcus aureus was the most frequently isolated bacterium from blood and tissue samples. Advanced MRI changes and complicated VO were more often observed in patients with high CCI score due to impaired immune system caused by chronic comorbid disease(s) or modulation of immunity with medications. High CCI scores were more frequently associated with positive blood cultures due to bacteremia because
of impaired immunity. Patients with complicated VO were longer treated with antibiotics parenterally and more often surgically treated for phlegmon and abscess formation. Liver cirrhosis and degenerative spine disease, which were more often found in patients with complicated VO, obviously impacted the course of the disease.

Ključne riječi

Osteomyelitis, spine; Magnetic resonance imaging; Comorbidity; Outcome assessment; Adult

Hrčak ID:

161266

URI

https://hrcak.srce.hr/161266

Datum izdavanja:

1.3.2016.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.034 *