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Original scientific paper

Changes in the Central Nervous Activity of Rats Treated with Dimethoate in Combination with Other Neurotoxicants in Different Phases of Ontogenesis

Zsuzsanna Lengyel
Zita Fazakas
Laszlo Nagymajtenyi

Fulltext: english, pdf (363 KB) pages 257-264 downloads: 870* cite
APA 6th Edition
Lengyel, Z., Fazakas, Z. & Nagymajtenyi, L. (2005). Changes in the Central Nervous Activity of Rats Treated with Dimethoate in Combination with Other Neurotoxicants in Different Phases of Ontogenesis. Arhiv za higijenu rada i toksikologiju, 56 (3), 257-264. Retrieved from https://hrcak.srce.hr/132
MLA 8th Edition
Lengyel, Zsuzsanna, et al. "Changes in the Central Nervous Activity of Rats Treated with Dimethoate in Combination with Other Neurotoxicants in Different Phases of Ontogenesis." Arhiv za higijenu rada i toksikologiju, vol. 56, no. 3, 2005, pp. 257-264. https://hrcak.srce.hr/132. Accessed 15 Apr. 2021.
Chicago 17th Edition
Lengyel, Zsuzsanna, Zita Fazakas and Laszlo Nagymajtenyi. "Changes in the Central Nervous Activity of Rats Treated with Dimethoate in Combination with Other Neurotoxicants in Different Phases of Ontogenesis." Arhiv za higijenu rada i toksikologiju 56, no. 3 (2005): 257-264. https://hrcak.srce.hr/132
Harvard
Lengyel, Z., Fazakas, Z., and Nagymajtenyi, L. (2005). 'Changes in the Central Nervous Activity of Rats Treated with Dimethoate in Combination with Other Neurotoxicants in Different Phases of Ontogenesis', Arhiv za higijenu rada i toksikologiju, 56(3), pp. 257-264. Available at: https://hrcak.srce.hr/132 (Accessed 15 April 2021)
Vancouver
Lengyel Z, Fazakas Z, Nagymajtenyi L. Changes in the Central Nervous Activity of Rats Treated with Dimethoate in Combination with Other Neurotoxicants in Different Phases of Ontogenesis. Arh Hig Rada Toksikol. [Internet]. 2005 [cited 2021 April 15];56(3):257-264. Available from: https://hrcak.srce.hr/132
IEEE
Z. Lengyel, Z. Fazakas and L. Nagymajtenyi, "Changes in the Central Nervous Activity of Rats Treated with Dimethoate in Combination with Other Neurotoxicants in Different Phases of Ontogenesis", Arhiv za higijenu rada i toksikologiju, vol.56, no. 3, pp. 257-264, 2005. [Online]. Available: https://hrcak.srce.hr/132. [Accessed: 15 April 2021]

Abstracts
Organophosphates are usually found in the environment with other pesticides and with pollutants of industrial origin can cause combined exposure involving unknown interactions between the agents. In this study, female Wistar rats were given 1/25 LD50 of dimethoate by gavage, combined with the same LD50 fractions of propoxur and cypermethrin or with arsenic (6.66 mg kg-1). The doses were given from day 5 to 15 of pregnancy, or that plus for the 4 weeks of lactation, or that plus 8 weeks for the male offspring after weaning. Control rats received distilled water. Electrophysiological recording was done when the male offspring reached 12 weeks of age. Spontaneous activity and evoked potentials from the somatosensory, visual and auditory cortex; and conduction velocity and absolute and relative refractory periods of the tail nerve were measured. The general trend was a shift of the spontaneous cortical activity to higher frequencies and increase in the evoked potential latency. The results showed that combined exposure to several environmental toxicants could be more harmful than the effects of each substance alone, indicating the importance of combination toxicology in modelling human effects. Furthermore, these results emphasize the importance of avoiding toxic exposures in pregnant and nursing women.

Keywords
central nervous activity; development; dimethoate; heavy metals; insecticides; neurotoxicants; neurotoxicity; ontogenesis; rats

Hrčak ID: 132

URI
https://hrcak.srce.hr/132

[croatian]

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