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THE EFFECT OF SELECTED POLYMORPHISMS OF THE DOPAMINE RECEPTOR GENE DRD2 AND THE ANKK-1 ON THE PREFERENCE OF CONCENTRATIONS OF SUCROSE SOLUTIONS IN MEN WITH ALCOHOL DEPENDENCE

Marcin Jabłoński ; Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland
Andrzej Jasiewicz ; Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland
Jolanta Kucharska-Mazur ; Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland
Jerzy Samochowiec ; Department of Psychiatry, Pomeranian Medical University, Szczecin, Poland
Przemyslaw Bienkowski ; Department of Pharmacology Institute of Psychiatry and Neurology, Warsaw, Poland
Pawel Mierzejewski ; Department of Pharmacology Institute of Psychiatry and Neurology, Warsaw, Poland
Agnieszka Samochowiec ; Institute of Psychology, Department of Clinical Psychology, University of Szczecin, Szczecin, Poland

Sažetak

Background: The aim of the study was to determine the influence of DRD2 gene polymorphisms in exon 8 G/A (rs 6276) in the
promoter region -141 C Ins/Del (rs1799732) and the influence of ANKK-1 gene Taq-1A polymorphism (rs 1800497) on the
preference of increasing sucrose concentrations in men with alcohol dependence.
Subjects and methods: 63 male patients with alcohol dependence were genotyped for the above polymorphisms. Their preference
for increasing sucrose concentrations was tested and their taste intensity perception of sucrose solutions was assessed. The patients
were tested with the 'Sniffin' Sticks' olfactory test.
Results: We found a statistically significant association between some alleles of ANKK 1 gene Taq 1A polymorphisms and sucrose
preference in the subjects. The A1 Taq 1A allele determined hedonistic response to the two highest concentrations of sucrose. No
association was found regarding the other two polymorphisms (in the promoter region and in the exon 8 of the DRD2 gene).
Conclusions: Study results suggest Taq-1A polymorphism plays a role in the preference to high concentrations of sucrose and its
potential association with alcohol dependence pathogenesis.

Ključne riječi

alcohol dependence - DRD2 gene polymorphisms - ANKK 1 gene polymorphisms - sucrose preference

Hrčak ID:

162110

URI

https://hrcak.srce.hr/162110

Datum izdavanja:

16.12.2013.

Posjeta: 508 *