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IMPACT OF DIFFERENT ANTIPSYCHOTICS ON CYTOKINES AND TRYPTOPHAN METABOLITES IN STIMULATED CULTURES FROM PATIENTS WITH SCHIZOPHRENIA

Daniela Krause orcid.org/0000-0003-0966-2521 ; Department of Psychiatry, Ludwig Maximilian University Munich, Germany
Elif Weidinger ; Department of Psychiatry, Ludwig Maximilian University Munich, Germany
Catherine Dippel ; Department of Psychiatry, Ludwig Maximilian University Munich, Germany
Michael Riedel ; Department of Psychiatry, Ludwig Maximilian University Munich, Germany; Vinzenz von Paul Hospital, Rottweil, Germany
Markus J. Schwarz ; Department of Psychiatry, Ludwig Maximilian University Munich, Germany
Norbert Müller ; Department of Psychiatry, Ludwig Maximilian University Munich, Germany
Aye-Mu Myint ; Department of Psychiatry, Ludwig Maximilian University Munich, Germany

Sažetak

Background: An imbalance of tryptophan metabolites plays a role in the pathophysiology of schizophrenia. Also cytokines seem
to be involved and are able to enhance the tryptophan metabolism. In this study the impact of cytokines, tryptophan metabolites and
antipsychotics was evaluated in schizophrenic patients/ healthy controls and correlated with the psychopathology of schizophrenia.
Subjects and methods: This study investigated 12 patients with schizophrenia and 24 matched controls. Peripheral blood
mononuclear cell cultures were stimulated in vitro with lipopolysaccharide (LPS) or polyinosine-polycytidylic acid (poly I:C) and
different antipsychotics (quetiapine, risperidone, haloperidole and clozapine) were added. The cytokines IL-4, IL-10, IFN-γ and
tryptophan metabolites were analysed. Symptom severity was assessed using the positive and negative syndrome scale (PANSS).
Results: Peripheral mononuclear cells of schizophrenia patients showed a reduced IFN-γ response to LPS (p=0.008). When
quetiapine and risperidone were added this imbalance between patients and controls disappeared. Tryptophan levels were
significantly lower in patients’ cells cultures when the cells were stimulated with LPS (p=0.029). A group effect for lower levels in
the patients’ cell culture was evaluated for tryptophan and kynurenine (p=0.043; p=0.05). In addition, high tryptophan levels
correlated with low PANSS negative scores in patients and higher kynurenine levels resulted in higher PANSS positive scores.
Conclusions: Only two atypical antipsychotics were identified to reverse the imbalanced cytokine levels in schizophrenia. The
low concentrations of tryptophan and kynurenine in these patients could be a sign of a fast degradation of tryptophan – yet
tryptophan metabolites could not be changed by any of the investigated antipsychotics.

Ključne riječi

schizophrenia – tryptophan – risperidone – quetiapine - cytokines

Hrčak ID:

162115

URI

https://hrcak.srce.hr/162115

Datum izdavanja:

16.12.2013.

Posjeta: 591 *