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THE OXIDATIVE STRESS HYPOTHESIS IN ALZHEIMER’S DISEASE

Manuela Padurariu ; “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Alin Ciobica ; "Alexandru Ioan Cuza" University, Iasi, Romania; Center of Biomedical Research of the Romanian Academy, Iasi Branch, Romania
Radu Lefter ; "Alexandru Ioan Cuza" University, Iasi, Romania
Ionela Lacramioara Serban ; “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Cristinel Stefanescu ; “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Roxana Chirita ; “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania

Puni tekst: engleski, pdf (213 KB) str. 0-409 preuzimanja: 648* citiraj
APA 6th Edition
Padurariu, M., Ciobica, A., Lefter, R., Lacramioara Serban, I., Stefanescu, C. i Chirita, R. (2013). THE OXIDATIVE STRESS HYPOTHESIS IN ALZHEIMER’S DISEASE. Psychiatria Danubina, 25 (4), 0-409. Preuzeto s https://hrcak.srce.hr/162117
MLA 8th Edition
Padurariu, Manuela, et al. "THE OXIDATIVE STRESS HYPOTHESIS IN ALZHEIMER’S DISEASE." Psychiatria Danubina, vol. 25, br. 4, 2013, str. 0-409. https://hrcak.srce.hr/162117. Citirano 09.04.2020.
Chicago 17th Edition
Padurariu, Manuela, Alin Ciobica, Radu Lefter, Ionela Lacramioara Serban, Cristinel Stefanescu i Roxana Chirita. "THE OXIDATIVE STRESS HYPOTHESIS IN ALZHEIMER’S DISEASE." Psychiatria Danubina 25, br. 4 (2013): 0-409. https://hrcak.srce.hr/162117
Harvard
Padurariu, M., et al. (2013). 'THE OXIDATIVE STRESS HYPOTHESIS IN ALZHEIMER’S DISEASE', Psychiatria Danubina, 25(4), str. 0-409. Preuzeto s: https://hrcak.srce.hr/162117 (Datum pristupa: 09.04.2020.)
Vancouver
Padurariu M, Ciobica A, Lefter R, Lacramioara Serban I, Stefanescu C, Chirita R. THE OXIDATIVE STRESS HYPOTHESIS IN ALZHEIMER’S DISEASE. Psychiatria Danubina [Internet]. 2013 [pristupljeno 09.04.2020.];25(4):0-409. Dostupno na: https://hrcak.srce.hr/162117
IEEE
M. Padurariu, A. Ciobica, R. Lefter, I. Lacramioara Serban, C. Stefanescu i R. Chirita, "THE OXIDATIVE STRESS HYPOTHESIS IN ALZHEIMER’S DISEASE", Psychiatria Danubina, vol.25, br. 4, str. 0-409, 2013. [Online]. Dostupno na: https://hrcak.srce.hr/162117. [Citirano: 09.04.2020.]

Sažetak
Oxidative stress may be involved in many somatic and psychiatric pathological states including dementia. The hypothesis of
oxidative stress involvement in dementia is supported by much scientific data through biochemical, genetic and molecular studies.
Thus, there are many reports of an increased level of the markers for oxidative damage, alterations in the specific activity of the
antioxidant system, mutations in specific genes, mitochondrial disturbances and also several connections between oxidative stress
and amyloid plaques. Despite these evidence and clinical approaches in using antioxidant therapy in dementia treatment, studies
have failed to prove a clear benefit for antioxidant treatment in dementia. Hence, there is a need for further research regarding
antioxidant therapy in very early stages of dementia.

Ključne riječi
Alzheimer – dementia - oxidative stress - antioxidant

Hrčak ID: 162117

URI
https://hrcak.srce.hr/162117

Posjeta: 713 *