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The effect of D-penicillamine on experimental silicosis in rats

A. Anđelovski ; Institut za medicinu rada i radiološku zaštitu SR Srbije, Beograd
V. Višnjić ; Institut za medicinu rada i radiološku zaštitu SR Srbije, Beograd
B. Anđelovska ; Institut za medicinu rada i radiološku zaštitu SR Srbije, Beograd
S. Dodić ; Institut za medicinu rada i radiološku zaštitu SR Srbije, Beograd
A. Vidaković ; Institut za medicinu rada i radiološku zaštitu SR Srbije, Beograd

Puni tekst: srpski, pdf (9 MB) str. 115-124 preuzimanja: 92* citiraj
APA 6th Edition
Anđelovski, A., Višnjić, V., Anđelovska, B., Dodić, S. i Vidaković, A. (1978). Uticaj d-penicilamina na eksperimentalnu silikozu pacova. Arhiv za higijenu rada i toksikologiju, 29 (2), 115-124. Preuzeto s https://hrcak.srce.hr/162178
MLA 8th Edition
Anđelovski, A., et al. "Uticaj d-penicilamina na eksperimentalnu silikozu pacova." Arhiv za higijenu rada i toksikologiju, vol. 29, br. 2, 1978, str. 115-124. https://hrcak.srce.hr/162178. Citirano 24.09.2020.
Chicago 17th Edition
Anđelovski, A., V. Višnjić, B. Anđelovska, S. Dodić i A. Vidaković. "Uticaj d-penicilamina na eksperimentalnu silikozu pacova." Arhiv za higijenu rada i toksikologiju 29, br. 2 (1978): 115-124. https://hrcak.srce.hr/162178
Harvard
Anđelovski, A., et al. (1978). 'Uticaj d-penicilamina na eksperimentalnu silikozu pacova', Arhiv za higijenu rada i toksikologiju, 29(2), str. 115-124. Preuzeto s: https://hrcak.srce.hr/162178 (Datum pristupa: 24.09.2020.)
Vancouver
Anđelovski A, Višnjić V, Anđelovska B, Dodić S, Vidaković A. Uticaj d-penicilamina na eksperimentalnu silikozu pacova. Arh Hig Rada Toksikol. [Internet]. 1978 [pristupljeno 24.09.2020.];29(2):115-124. Dostupno na: https://hrcak.srce.hr/162178
IEEE
A. Anđelovski, V. Višnjić, B. Anđelovska, S. Dodić i A. Vidaković, "Uticaj d-penicilamina na eksperimentalnu silikozu pacova", Arhiv za higijenu rada i toksikologiju, vol.29, br. 2, str. 115-124, 1978. [Online]. Dostupno na: https://hrcak.srce.hr/162178. [Citirano: 24.09.2020.]

Sažetak
The effect of D-penicillamine on silicosis was studied in 40 rats divided into four groups, ten in each group. Three groups received 50 mg of silicon dioxide intratracheally. The fourth group served as control. Among the exposed groups one was not treated with D-penicillamine and served as positive control. The rats in the second group were each given 10 mg D-penicilIamine (Metalcaptase »Pliva«) in drinking water every day. The third group was also treated with D-penicillamine and received about 5 mg per rat in drinking water every day. The rats were killed seven months after the first administration of penicillamine, i. e. after 15 months of SiO2 exposure. The rats were weighted at the beginning of the experiment and after 1, 3, 8 and 15 months. The lungs were also weighted. The lungs of rats in the third group weighted less, by 0.5 g, than those in the silicotic group. However, a histological analysis of the lungs and lymph nodes from the mediastinum showed some changes which proved that under the influence of D-penicillamine a regression i. e. decomposition of the collagen fibre took: place, especially in the group of rats which received a lower dose of penicillamine. On the basis of the histological analysis and the weight of the lungs we concluded that penicillamine in smaller doses causes decomposition of the collagen fibre.

Hrčak ID: 162178

URI
https://hrcak.srce.hr/162178

[srpski]

Posjeta: 214 *