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Original scientific paper

ELEVATED NEUTROPHIL/LYMPHOCYTE RATIO IN PATIENTS WITH SCHIZOPHRENIA

Murat Semiz ; Department of Psychiatry, Gaziozmanpasa University School of Medicine, Tokat, Turkey
Osman Yildirim ; Department of Psychiatry, Abant Izzet Baysal University School of Medicine, Bolu, Turkey
Fatih Canan ; Department of Psychiatry, Akdeniz University School of Medicine, Antalya, Turkey
Suleyman Demir ; Department of Psychiatry, Dicle University School of Medicine, Diyarbakir, Turkey
Ekrem Hasbek ; Clinic of Psychiatry, Sivas State Hospital, Sivas, Turkey
Taha Can Tuman ; Department of Psychiatry, Abant Izzet Baysal University School of Medicine, Bolu, Turkey
Nefise Kayka ; Department of Psychiatry, Abant Izzet Baysal University School of Medicine, Bolu, Turkey
Mehmet Tosun ; Department of Medical Biochemistry, Abant Izzet Baysal University School of Medicine, Bolu, Turkey

Fulltext: english, pdf (102 KB) pages 0-225 downloads: 364* cite
APA 6th Edition
Semiz, M., Yildirim, O., Canan, F., Demir, S., Hasbek, E., Tuman, T.C., ... Tosun, M. (2014). ELEVATED NEUTROPHIL/LYMPHOCYTE RATIO IN PATIENTS WITH SCHIZOPHRENIA. Psychiatria Danubina, 26 (3), 0-225. Retrieved from https://hrcak.srce.hr/162193
MLA 8th Edition
Semiz, Murat, et al. "ELEVATED NEUTROPHIL/LYMPHOCYTE RATIO IN PATIENTS WITH SCHIZOPHRENIA." Psychiatria Danubina, vol. 26, no. 3, 2014, pp. 0-225. https://hrcak.srce.hr/162193. Accessed 25 Sep. 2020.
Chicago 17th Edition
Semiz, Murat, Osman Yildirim, Fatih Canan, Suleyman Demir, Ekrem Hasbek, Taha Can Tuman, Nefise Kayka and Mehmet Tosun. "ELEVATED NEUTROPHIL/LYMPHOCYTE RATIO IN PATIENTS WITH SCHIZOPHRENIA." Psychiatria Danubina 26, no. 3 (2014): 0-225. https://hrcak.srce.hr/162193
Harvard
Semiz, M., et al. (2014). 'ELEVATED NEUTROPHIL/LYMPHOCYTE RATIO IN PATIENTS WITH SCHIZOPHRENIA', Psychiatria Danubina, 26(3), pp. 0-225. Available at: https://hrcak.srce.hr/162193 (Accessed 25 September 2020)
Vancouver
Semiz M, Yildirim O, Canan F, Demir S, Hasbek E, Tuman TC, et al. ELEVATED NEUTROPHIL/LYMPHOCYTE RATIO IN PATIENTS WITH SCHIZOPHRENIA. Psychiatria Danubina [Internet]. 2014 [cited 2020 September 25];26(3):0-225. Available from: https://hrcak.srce.hr/162193
IEEE
M. Semiz, et al., "ELEVATED NEUTROPHIL/LYMPHOCYTE RATIO IN PATIENTS WITH SCHIZOPHRENIA", Psychiatria Danubina, vol.26, no. 3, pp. 0-225, 2014. [Online]. Available: https://hrcak.srce.hr/162193. [Accessed: 25 September 2020]

Abstracts
Background: Inflammatory mechanisms are reported to play important roles in the pathophysiology of schizophrenia. The
neutrophil–lymphocyte ratio (NLR) is a simple and easily accessible indicator of the systemic inflammatory response. Our goal was
to investigate whether NLR was higher in patients with schizophrenia than in healthy comparison subjects similar in age, sex, and
body mass index.
Subjects and methods: In this multicenter cross-sectional study, we analyzed 156 non-obese patients with schizophrenia and 89
healthy control subjects for complete blood count. The Brief Psychiatric Rating Scale was used to determine the severity of clinical
pathology.
Results: The mean±SD NLR of patients with schizophrenia was significantly higher than that of healthy controls (2.6±1.1 vs.
1.9±0.6, respectively, p<0.001). NLR did not significantly correlate with severity and duration of schizophrenia (r=0.065. p>0.05).
Conclusions: Our findings suggest that NLR levels are increased in physically healthy, non-obese, patients with schizophrenia
when compared with physically and mentally healthy individuals. To our knowledge, this is the first study that demonstrated the
association between NLR and schizophrenia.

Keywords
lymphocyte – neutrophil - neutrophil/lymphocyte ratio – schizophrenia – inflammation - immunology

Hrčak ID: 162193

URI
https://hrcak.srce.hr/162193

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