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Professional paper

COGNITIVE FUNCTION IN EARLY CLINICAL PHASE HUNTINGTON DISEASE AFTER RIVASTIGMINE TREATMENT

Sanja Šešok   ORCID icon orcid.org/0000-0001-6415-4752 ; Division of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia
Nika Bolle ; Division of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia
Jan Kobal ; Division of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia
Valentin Bucik ; Department of Psychology, Faculty of Arts, University of Ljubljana, Ljubljana, Slovenia
David B.Vodušek ; Division of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia

Fulltext: english, pdf (263 KB) pages 239-248 downloads: 131* cite
APA 6th Edition
Šešok, S., Bolle, N., Kobal, J., Bucik, V. & B.Vodušek, D. (2014). COGNITIVE FUNCTION IN EARLY CLINICAL PHASE HUNTINGTON DISEASE AFTER RIVASTIGMINE TREATMENT. Psychiatria Danubina, 26 (3), 239-248. Retrieved from https://hrcak.srce.hr/162197
MLA 8th Edition
Šešok, Sanja, et al. "COGNITIVE FUNCTION IN EARLY CLINICAL PHASE HUNTINGTON DISEASE AFTER RIVASTIGMINE TREATMENT." Psychiatria Danubina, vol. 26, no. 3, 2014, pp. 239-248. https://hrcak.srce.hr/162197. Accessed 20 Sep. 2020.
Chicago 17th Edition
Šešok, Sanja, Nika Bolle, Jan Kobal, Valentin Bucik and David B.Vodušek. "COGNITIVE FUNCTION IN EARLY CLINICAL PHASE HUNTINGTON DISEASE AFTER RIVASTIGMINE TREATMENT." Psychiatria Danubina 26, no. 3 (2014): 239-248. https://hrcak.srce.hr/162197
Harvard
Šešok, S., et al. (2014). 'COGNITIVE FUNCTION IN EARLY CLINICAL PHASE HUNTINGTON DISEASE AFTER RIVASTIGMINE TREATMENT', Psychiatria Danubina, 26(3), pp. 239-248. Available at: https://hrcak.srce.hr/162197 (Accessed 20 September 2020)
Vancouver
Šešok S, Bolle N, Kobal J, Bucik V, B.Vodušek D. COGNITIVE FUNCTION IN EARLY CLINICAL PHASE HUNTINGTON DISEASE AFTER RIVASTIGMINE TREATMENT. Psychiatria Danubina [Internet]. 2014 [cited 2020 September 20];26(3):239-248. Available from: https://hrcak.srce.hr/162197
IEEE
S. Šešok, N. Bolle, J. Kobal, V. Bucik and D. B.Vodušek, "COGNITIVE FUNCTION IN EARLY CLINICAL PHASE HUNTINGTON DISEASE AFTER RIVASTIGMINE TREATMENT", Psychiatria Danubina, vol.26, no. 3, pp. 239-248, 2014. [Online]. Available: https://hrcak.srce.hr/162197. [Accessed: 20 September 2020]

Abstracts
Background: In Huntington disease (HD) patients receiving rivastigmine treatment improvement of behavioral symptoms and of
cognitive function (assessed with screening diagnostic instruments) has been reported. The aim of the present study was to verify
such improvement in cognitive function by cognitive function assessment with a detailed neuropsychological battery covering all
relevant cognitive systems expected to be impaired in early phase HD.
Subjects and methods: Eighteen (18) HD patients entered the study and were randomly allocated to the rivastigmine and
placebo group. All subjects underwent neuropsychological assessment at baseline. Follow-up neuropsychological assessment was
applied after 6 months of rivastigmine or placebo treatment. Eighteen (18) healthy controls entered the study to control for practice
effect and underwent neuropsychological assessment at baseline and after 6 months, without treatment. The neuropsychological
battery consisted of assessment tools that are sensitive to cognitive impairment seen in early phase HD: CTMT, SDMT, Stroop
(attention and information control), RFFT, TOL, Verbal fluency (executive functioning), CVLT-II, RCFT (learning and memory).
Effect of rivastigmine and possible effect of practice was assessed using the mixed ANOVA model.
Results: No statistically significant effect of rivastigmine treatment on cognitive function in HD patients was detected. There was
no evidence for practice or placebo effect.
Conclusions: Detailed neuropsychological assessment did not confirm previously reported effect of rivastigmine treatment on
cognitive function in HD patients. The limitations of our study are, in particular, small sample size and the lack of a single measure
of relevant cognitive functioning in HD patients. Instead of focusing solely on statistical significance, a clinical relevance study is
proposed to clarify the issue of rivastigmine effects in HD.

Keywords
Huntington Disease – rivastigmine – neuropsychology - cognitive function

Hrčak ID: 162197

URI
https://hrcak.srce.hr/162197

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