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https://doi.org/10.21860/52;3_408

Prognostic value of invasive tumor front grading in squamous cell carcinoma of oral cavity

Manuela Avirović ; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Koviljka Matušan-Ilijaš ; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Mirna Juretić ; Klinika za oralnu i maksilofacijalnu kirurgiju, KBC Rijeka,
Robert Cerović ; Klinika za oralnu i maksilofacijalnu kirurgiju, KBC Rijeka,
Nives Jonjić ; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Ksenija Lučin ; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka

Puni tekst: hrvatski, pdf (1 MB) str. 408-414 preuzimanja: 499* citiraj
APA 6th Edition
Avirović, M., Matušan-Ilijaš, K., Juretić, M., Cerović, R., Jonjić, N. i Lučin, K. (2016). Prognostički značaj morfologije invazivne tumorske fronte u karcinomu pločastih stanica usne šupljine. Medicina Fluminensis, 52 (3), 408-414. https://doi.org/10.21860/52;3_408
MLA 8th Edition
Avirović, Manuela, et al. "Prognostički značaj morfologije invazivne tumorske fronte u karcinomu pločastih stanica usne šupljine." Medicina Fluminensis, vol. 52, br. 3, 2016, str. 408-414. https://doi.org/10.21860/52;3_408. Citirano 01.12.2020.
Chicago 17th Edition
Avirović, Manuela, Koviljka Matušan-Ilijaš, Mirna Juretić, Robert Cerović, Nives Jonjić i Ksenija Lučin. "Prognostički značaj morfologije invazivne tumorske fronte u karcinomu pločastih stanica usne šupljine." Medicina Fluminensis 52, br. 3 (2016): 408-414. https://doi.org/10.21860/52;3_408
Harvard
Avirović, M., et al. (2016). 'Prognostički značaj morfologije invazivne tumorske fronte u karcinomu pločastih stanica usne šupljine', Medicina Fluminensis, 52(3), str. 408-414. https://doi.org/10.21860/52;3_408
Vancouver
Avirović M, Matušan-Ilijaš K, Juretić M, Cerović R, Jonjić N, Lučin K. Prognostički značaj morfologije invazivne tumorske fronte u karcinomu pločastih stanica usne šupljine. Medicina Fluminensis [Internet]. 2016 [pristupljeno 01.12.2020.];52(3):408-414. https://doi.org/10.21860/52;3_408
IEEE
M. Avirović, K. Matušan-Ilijaš, M. Juretić, R. Cerović, N. Jonjić i K. Lučin, "Prognostički značaj morfologije invazivne tumorske fronte u karcinomu pločastih stanica usne šupljine", Medicina Fluminensis, vol.52, br. 3, str. 408-414, 2016. [Online]. https://doi.org/10.21860/52;3_408

Sažetak
Aim: To establish invasive tumor front grade (ITFG) in squamous cell carcinoma of the oral cavity (OCSCC), compare it with traditional histological grade and to investigate the prognostic value of both. Materials and methods: The whole tumor-tissue sections, stained with HE of 86 OCSCC cases were evaluated for the invasive tumor front grade and compared with the clinicopathological prognostic parameters such as pathological stage (pT stage), pathological lymph node stage (pN stage), clinical stage (TNM stage) and length of survival of patients. Tissue has been disposed at the Department of Maxillofacial Surgery, University Hospital Rijeka. Data of traditional histological grade were obtained from previous histological findings. Results: Traditional histological grade was not significantly associated with clinical parameters or survival of patients (P = 0.906). High ITFG was associated with positive lymph nodes (P = 0.006) and clinical stage of disease (P = 0.025), but not to pathological T stage (P = 0.086). In univariate analysis high ITFG was associated with shorter survival of patients (P = 0.001), and multivariate analysis showed it as the independent prognostic factor (P = 0.006). For individual parameters that determine ITFG like inflammatory infiltrate, way of invasion and degree of keratinization was also established statistically significant prognostic value in univariate (P < 0.001, P = 0.013, i.e., P = 0.009) and multivariate analysis. Conclusion: ITFG has greater prognostic value than the traditional histological grade. Determination of ITFG may help identify patients with a higher risk of disease recurrence after surgical removal of the tumor, which would use additional methods of treatment.

Ključne riječi
squamous cell carcinoma of the head and neck; survival analysis; tumor grading

Hrčak ID: 163960

URI
https://hrcak.srce.hr/163960

[hrvatski]

Posjeta: 696 *