Skoči na glavni sadržaj

Izvorni znanstveni članak

https://doi.org/10.21860/52;3_408

Prognostic value of invasive tumor front grading in squamous cell carcinoma of oral cavity

Manuela Avirović orcid id orcid.org/0000-0002-6601-7521 ; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Koviljka Matušan-Ilijaš ; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Mirna Juretić ; Klinika za oralnu i maksilofacijalnu kirurgiju, KBC Rijeka,
Robert Cerović ; Klinika za oralnu i maksilofacijalnu kirurgiju, KBC Rijeka,
Nives Jonjić ; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Ksenija Lučin ; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka


Puni tekst: hrvatski pdf 1.026 Kb

str. 408-414

preuzimanja: 1.588

citiraj


Sažetak

Aim: To establish invasive tumor front grade (ITFG) in squamous cell carcinoma of the oral cavity (OCSCC), compare it with traditional histological grade and to investigate the prognostic value of both. Materials and methods: The whole tumor-tissue sections, stained with HE of 86 OCSCC cases were evaluated for the invasive tumor front grade and compared with the clinicopathological prognostic parameters such as pathological stage (pT stage), pathological lymph node stage (pN stage), clinical stage (TNM stage) and length of survival of patients. Tissue has been disposed at the Department of Maxillofacial Surgery, University Hospital Rijeka. Data of traditional histological grade were obtained from previous histological findings. Results: Traditional histological grade was not significantly associated with clinical parameters or survival of patients (P = 0.906). High ITFG was associated with positive lymph nodes (P = 0.006) and clinical stage of disease (P = 0.025), but not to pathological T stage (P = 0.086). In univariate analysis high ITFG was associated with shorter survival of patients (P = 0.001), and multivariate analysis showed it as the independent prognostic factor (P = 0.006). For individual parameters that determine ITFG like inflammatory infiltrate, way of invasion and degree of keratinization was also established statistically significant prognostic value in univariate (P < 0.001, P = 0.013, i.e., P = 0.009) and multivariate analysis. Conclusion: ITFG has greater prognostic value than the traditional histological grade. Determination of ITFG may help identify patients with a higher risk of disease recurrence after surgical removal of the tumor, which would use additional methods of treatment.

Ključne riječi

squamous cell carcinoma of the head and neck; survival analysis; tumor grading

Hrčak ID:

163960

URI

https://hrcak.srce.hr/163960

Datum izdavanja:

1.9.2016.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.460 *