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Pregledni rad
https://doi.org/10.21860/52;3_283

Descriptive and functional definition of nucleolus – a pathway to cancer therapy

Mira Krstulja ; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Gordana Đorđević ; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Irena Seili-Bekafigo ; Zavod za kliničku citologiju, KBC Rijeka,
Tamara Braut ; Klinika za otorinolaringologiju i kirurgiju glave i vrata, KBC Rijeka, Rijeka

Puni tekst: hrvatski, pdf (975 KB) str. 283-300 preuzimanja: 573* citiraj
APA 6th Edition
Krstulja, M., Đorđević, G., Seili-Bekafigo, I. i Braut, T. (2016). Deskriptivna i funkcionalna definicija jezgrice – put prema terapiji raka. Medicina Fluminensis, 52 (3), 283-300. https://doi.org/10.21860/52;3_283
MLA 8th Edition
Krstulja, Mira, et al. "Deskriptivna i funkcionalna definicija jezgrice – put prema terapiji raka." Medicina Fluminensis, vol. 52, br. 3, 2016, str. 283-300. https://doi.org/10.21860/52;3_283. Citirano 01.12.2020.
Chicago 17th Edition
Krstulja, Mira, Gordana Đorđević, Irena Seili-Bekafigo i Tamara Braut. "Deskriptivna i funkcionalna definicija jezgrice – put prema terapiji raka." Medicina Fluminensis 52, br. 3 (2016): 283-300. https://doi.org/10.21860/52;3_283
Harvard
Krstulja, M., et al. (2016). 'Deskriptivna i funkcionalna definicija jezgrice – put prema terapiji raka', Medicina Fluminensis, 52(3), str. 283-300. https://doi.org/10.21860/52;3_283
Vancouver
Krstulja M, Đorđević G, Seili-Bekafigo I, Braut T. Deskriptivna i funkcionalna definicija jezgrice – put prema terapiji raka. Medicina Fluminensis [Internet]. 2016 [pristupljeno 01.12.2020.];52(3):283-300. https://doi.org/10.21860/52;3_283
IEEE
M. Krstulja, G. Đorđević, I. Seili-Bekafigo i T. Braut, "Deskriptivna i funkcionalna definicija jezgrice – put prema terapiji raka", Medicina Fluminensis, vol.52, br. 3, str. 283-300, 2016. [Online]. https://doi.org/10.21860/52;3_283

Sažetak
Modern tumour therapy should be target specific and comprehensive. Recent clinical trials test small molecular inhibitors of transcription of ribosomal genes and activators of apoptosis. We treatise on models of activation of the suppressors of tumour growth acting in the nucleolar domain. Tumour cells demonstrate a disordered protein regulation and mutation of P53 gene which codes for a suppressor of growth. Therapy is guided by pathogenesis. Modern disease definition is based on etiopathogenesis of cell stress, wherein participate numerous organelles, including the nucleolus. Nucleus and nucleolus are forms seen on light microscopy. This presentation focuses on the description of the visible correlate of the notion of “nucleolus”. Further to this, acid non-histone proteins which gather around the transcriptional machinery of RNA polymerase I are described, and the significance of their visualisation towards the alteration of the definition of nucleolus is pointed out. Besides being a particle within the nucleoplasm and a subnuclear organelle, the nucleolus is visualized through its functional structures – the AgNORs. The AgNOR proteins have a role in nucleolar stress. The aim of this article is to discuss the nucleolar stress.

Ključne riječi
biological stress; carcinogenesis; cell nucleolus; disease; therapeutics

Hrčak ID: 163962

URI
https://hrcak.srce.hr/163962

[hrvatski]

Posjeta: 820 *