Acta clinica Croatica, Vol. 55. No. 2., 2016.
Ostalo
https://doi.org/10.20471/acc.2016.55.02.24
Drug-induced oral ulcerations: case report
Vanja Vučičević Boras
; Department of Oral Medicine, School of Dentistry, University of Zagreb, Zagreb, Croatia; Zagreb University Hospital Center, Zagreb, Croatia
Snježana Židovec-Lepej
; Department of Virology, Dr Fran Mihaljević Clinical Hospital for Infectious Diseases, Zagreb, Croatia
Branka Marinović
; Clinical Department of Dermatology and Venereology, Zagreb University Hospital Center, Zagreb, Croatia
Sven Seiwerth
; Department of Pathology, Zagreb University Hospital Center, Zagreb, Croatia
Ivana Škrinjar
; Department of Oral Medicine, School of Dentistry, University of Zagreb, Zagreb, Croatia; Zagreb University Hospital Center, Zagreb, Croatia
Dražen Pulanić
; Division of Hematology, Department of Internal Medicine, Zagreb University Hospital Center, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia ; Osijek School of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croat
Danica Vidović Juras
; Department of Oral Medicine, School of Dentistry, University of Zagreb, Zagreb, Croatia; Zagreb University Hospital Center, Zagreb, Croatia
Sažetak
A 70-year-old patient was admitted to the Department of Oral Medicine for multiple oral ulcerations on the left buccal mucosa, around 0.5 cm in diameter, as well as on the gingiva. Otherwise, the patient suffered from chronic lymphocytic leukemia, hypogammaglobulinemia, chronic renal insufficiency, with complete afunction of the right kidney, asthma, hypertension, gastritis and prostate hyperplasia. Differential diagnosis of oral ulcerations included drug induced oral ulcerations, paraneoplastic pemphigus, viral ulcerations (cytomegalovirus, herpes simplex viruses), fungal ulcerations (candidiasis, aspergillosis, histoplasmosis, cryptococcosis) and bacterial ulcerations, as well as neutropenic ulcers. One of the possible explanations was that the lesions were due to the use of drugs, the more so as oral lesions evolved when the doses of allopurinol and chlorambucil were increased, and subsided when the doses of both drugs were decreased. However, we could not establish
for sure whether the lesions were due to allopurinol or chlorambucil. According to literature data, allopurinol is one of the most frequent drugs known to induce skin adverse reactions, therefore we assumed that it was the culprit drug. Unfortunately, several weeks later the patient died from sepsis, pneumonia with respiratory insufficiency and multiorgan failure.
Ključne riječi
Oral ulcer; Drug-related side effects and adverse reactions; Case reports
Hrčak ID:
164896
URI
Datum izdavanja:
1.6.2016.
Posjeta: 2.020 *