Kratko priopćenje

https://doi.org/10.1515/acph-2016-0044

Pharmacokinetic evaluation of the interaction between oral kaempferol and ethanol in rats

ZHAOXIANG ZHOU ; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China
MENG WANG ; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China
ZENGJUN GUO ; Medical College of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China
XIAOYING ZHANG ; College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China

Sažetak

This study was aimed at investigating the effect of ethanol on oral bioavailability of kaempferol in rats, namely, at disclosing their possible interaction. Kaempferol (100 or 250 mg kg–1 bm) was administered to the rats by oral gavage with or without ethanol (600 mg kg–1 bm) co-administration. Intravenous administration (10 and 25 mg kg–1 bm) of kaempferol was used to determine the bioavailability. The concentration of kaempferol in plasma was estimated by ultra high performance liquid chromatography. During co-administration, significant increase of the area under the plasma concentration-time curve as well as the peak concentration were observed, along with a dramatic decrease in total body clearance. Consequently, the bioavailability of kaempferol in oral control groups was 3.1 % (100 mg kg–1 bm) and 2.1 % (250 mg kg–1 bm). The first was increased by 4.3 % and the other by 2.8 % during ethanol co-administration. Increased permeability of cell membrane and ethanol-kaempferol interactions on CYP450 enzymes may enhance the oral bioavailability of kaempferol in rats.

Ključne riječi

kaempferol; bioavailability; pharmacokinetics; ethanol; cytochrome P450s

Hrčak ID:

165022

URI

https://hrcak.srce.hr/165022

Datum izdavanja:

31.12.2016.

Posjeta: 1.520 *