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Acta Pharmaceutica, Vol. 67 No. 1, 2017.

Izvorni znanstveni članak

https://doi.org/10.1515/acph-2017-0002

Characterization and taste masking evaluation of microparticles with cetirizine dihydrochloride and methacrylate-based copolymer obtained by the spray drying

ALEKSANDRA AMELIAN ; Department of Pharmaceutical Technology, Medical University of Białystok, Białystok 15-222, Poland; Department of Clinical Pharmacy, Medical University of Białystok, Białystok 15-222, Poland
MARTA SZEKALSKA ; Department of Pharmaceutical Technology, Medical University of Białystok, Białystok 15-222, Poland
PATRYCJA CIOSEK ; Department of Microbioanalytics, Warsaw University of Technology, Warszawa 00-664, Poland
ANNA BASA ; Department of Physicochemical Analysis, University of Białystok, Białystok 15-399, Poland
KATARZYNA WINNICKA orcid id orcid.org/0000-0002-1013-610X ; Department of Pharmaceutical Technology, Medical University of Białystok, Białystok 15-222, Poland

Puni tekst: engleski pdf 1.935 Kb

str. 113-124

preuzimanja: 1.012

citiraj

Sažetak

Taste of a pharmaceutical formulation is an important parameter for the effectiveness of pharmacotherapy. Cetirizine dihydrochloride (CET) is a second-generation antihistamine that is commonly administered in allergy treatment. CET is characterized by extremely bitter taste and it is a great challenge to successfully mask its taste; therefore the goal of this work was to formulate and characterize the microparticles obtained by the spray drying method with CET and poly(butyl methacrylate-co-(2-dimethylaminoethyl) methacrylate-co-methyl methacrylate 1:2:1 copolymer (Eudragit E PO) as a barrier coating. Assessment of taste masking by the electronic tongue has revealed that designed formulations created an effective taste masking barrier. Taste masking effect was also confirmed by the in vivo model and the in vitro release profile of CET. Obtained data have shown that microparticles with a drug/polymer ratio (0.5:1) are promising CET carriers with efficient taste masking potential and might be further used in designing orodispersible dosage forms with CET.

Ključne riječi

taste masking; electronic tongue; cetirizine dihydrochloride; microparticles; methacrylate copolymer; spray drying

Hrčak ID:

165084

URI

https://hrcak.srce.hr/165084

Datum izdavanja:

31.3.2017.

Posjeta: 1.645 *