hrcak mascot   Srce   HID

Izvorni znanstveni članak

Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population

Vesna Horvat   ORCID icon orcid.org/0000-0001-9554-4278 ; Department of Clinical Laboratory Diagnostics, University Hospital Centre Osijek, Osijek
Sanja Mandić
Milanka Mrčela
Josip Galić

Puni tekst: engleski, pdf (235 KB) str. 393-400 preuzimanja: 73* citiraj
APA 6th Edition
Horvat, V., Mandić, S., Mrčela, M. i Galić, J. (2015). Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population. Collegium antropologicum, 39 (2), 393-400. Preuzeto s https://hrcak.srce.hr/166079
MLA 8th Edition
Horvat, Vesna, et al. "Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population." Collegium antropologicum, vol. 39, br. 2, 2015, str. 393-400. https://hrcak.srce.hr/166079. Citirano 15.07.2020.
Chicago 17th Edition
Horvat, Vesna, Sanja Mandić, Milanka Mrčela i Josip Galić. "Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population." Collegium antropologicum 39, br. 2 (2015): 393-400. https://hrcak.srce.hr/166079
Harvard
Horvat, V., et al. (2015). 'Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population', Collegium antropologicum, 39(2), str. 393-400. Preuzeto s: https://hrcak.srce.hr/166079 (Datum pristupa: 15.07.2020.)
Vancouver
Horvat V, Mandić S, Mrčela M, Galić J. Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population. Collegium antropologicum [Internet]. 2015 [pristupljeno 15.07.2020.];39(2):393-400. Dostupno na: https://hrcak.srce.hr/166079
IEEE
V. Horvat, S. Mandić, M. Mrčela i J. Galić, "Association of IL-1β and IL-10 Polymorphisms with Prostate Cancer Risk and Grade of Disease in Eastern Croatian Population", Collegium antropologicum, vol.39, br. 2, str. 393-400, 2015. [Online]. Dostupno na: https://hrcak.srce.hr/166079. [Citirano: 15.07.2020.]

Sažetak
Single nuclear polymorphisms (SNPs) in the promotor regions of cytokine genes included in angiogenesis may influence prostate cancer (PCa) development via regulation of the pathways of tumor angiogenesis. The aim of the present study was to investigate the association of IL-1β+3954 (rs1143634) and IL-10-1082 (rs1800896) polymorphisms with PCa risk and aggressiveness in eastern Croatian patients. One hundred twenty PCa patients and 120 benign prostatic hyperplasia (BPH) controls were genotyped using real-time PCR (LightCycler Instrument, Roche Diagnostics) and the melting curve analysis method. There was no significant difference in the frequency of genotypes for the two polymorphisms between PCa patients and controls (χ2=0.857, p=0.355 for IL-β1; χ2=0.026, p=0.872 for IL-10). Carriers of the IL-10-1082A>G variant were found to be associated with the Gleason score (GS)>7 (AA versus GA+GG, OR=3.47, 95% CI 1.11-10.88, p=0.033). There was no significant difference in the frequency of genotypes for the two polymorphisms and the presence of metastatic disease in PCa patients. These results suggest that tested SNPs associated with differential production of IL-1β and IL-10 are not risk factors for PCa and do not correlate with the presence of distant metastasis in eastern Croatians. We found that IL-10-1082 GA+/or GG carriers have a higher risk of developing PCa with GS>7 in eastern Croatians.

Ključne riječi
prostate cancer; benign prostatic hyperplasia; Gleason score; angiogenesis; SNP; interleukin-1β; interleukin-10; eastern Croatia; risk; grade

Hrčak ID: 166079

URI
https://hrcak.srce.hr/166079

Posjeta: 143 *