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Arhiv za higijenu rada i toksikologiju, Vol. 27 No. 1, 1976.

Izvorni znanstveni članak

Acute toxicity and cholinesterase inhibition in vivo of chlorthiophos

G. Muačević ; C. H. Boehringer Sohn, Abt. Pharmakologie, Ingelheim am Rhein, F. R. Germany

Puni tekst: engleski, pdf (8 MB) str. 3-14 preuzimanja: 43* citiraj
APA 6th Edition
Muačević, G. (1976). Acute toxicity and cholinesterase inhibition in vivo of chlorthiophos. Arhiv za higijenu rada i toksikologiju, 27 (1), 3-14. Preuzeto s https://hrcak.srce.hr/166181
MLA 8th Edition
Muačević, G.. "Acute toxicity and cholinesterase inhibition in vivo of chlorthiophos." Arhiv za higijenu rada i toksikologiju, vol. 27, br. 1, 1976, str. 3-14. https://hrcak.srce.hr/166181. Citirano 16.02.2019.
Chicago 17th Edition
Muačević, G.. "Acute toxicity and cholinesterase inhibition in vivo of chlorthiophos." Arhiv za higijenu rada i toksikologiju 27, br. 1 (1976): 3-14. https://hrcak.srce.hr/166181
Harvard
Muačević, G. (1976). 'Acute toxicity and cholinesterase inhibition in vivo of chlorthiophos', Arhiv za higijenu rada i toksikologiju, 27(1), str. 3-14. Preuzeto s: https://hrcak.srce.hr/166181 (Datum pristupa: 16.02.2019.)
Vancouver
Muačević G. Acute toxicity and cholinesterase inhibition in vivo of chlorthiophos. Arh Hig Rada Toksikol. [Internet]. 1976 [pristupljeno 16.02.2019.];27(1):3-14. Dostupno na: https://hrcak.srce.hr/166181
IEEE
G. Muačević, "Acute toxicity and cholinesterase inhibition in vivo of chlorthiophos", Arhiv za higijenu rada i toksikologiju, vol.27, br. 1, str. 3-14, 1976. [Online]. Dostupno na: https://hrcak.srce.hr/166181. [Citirano: 16.02.2019.]

Sažetak
The acute toxicity of chlorthiophos with a chief component 0,0-diethyl-0-[2,5-dichloro.4-(methylthio) phenyl] thionophosphate, combined with 0,0-diethyl-0-[ 4,5-dichloro-2-(methylthio) phenyl] thionophosphate and 0,0-diethyl-0-[2,4-dichloro-5-(methylthio) phenyl] thionophosphate is described. The oral LD50 values obtained are: rat, 13 mg/kg; mouse, 141 mg/kg; guinea-pig, 511 mg/kg; rabbit, 20 mg/kg; quaal, 45 mg/kg; hen, 45 mg/kg, and dermal LD50 for: rat, 58 mg/kg and for rabbit, 48 mg/kg. No signs of neurotoxicity in hens were observed. In rats, a maximal inhibition of erythrocyte cholinesterase was found after two hours, of plasma cholinesterase after four and of brain cholinesterase after six hours, with a reversal to normal in the blood observed after four days and in brain after eight days. Lindane and phenobarbital pretreatment reduced the acute toxicity of chlorthiophos. Atropine and some oximes (obidoximechloride and trimedoximebromide) antagonized the toxic effects of chlorthiophos.

Hrčak ID: 166181

URI
https://hrcak.srce.hr/166181

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