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Reactivation of phosphorylated cholinesterases in vitro and protecting effects in vivo of some pyridinium and quinolinium oximes

Vera Simeon ; Institute for Medical Research and Occupational Health, Yugoslav Academy of Sciences and Arts, Zagreb
Mira Škrinjarić-Špoljar ; Institute for Medical Research and Occupational Health, Yugoslav Academy of Sciences and Arts, Zagreb
Katja Wilhelm ; Institute for Medical Research and Occupational Health, Yugoslav Academy of Sciences and Arts, Zagreb

Puni tekst: engleski, pdf (5 MB) str. 11-17 preuzimanja: 78* citiraj
APA 6th Edition
Simeon, V., Škrinjarić-Špoljar, M. i Wilhelm, K. (1973). Reactivation of phosphorylated cholinesterases in vitro and protecting effects in vivo of some pyridinium and quinolinium oximes. Arhiv za higijenu rada i toksikologiju, 24 (1), 11-17. Preuzeto s https://hrcak.srce.hr/168186
MLA 8th Edition
Simeon, Vera, et al. "Reactivation of phosphorylated cholinesterases in vitro and protecting effects in vivo of some pyridinium and quinolinium oximes." Arhiv za higijenu rada i toksikologiju, vol. 24, br. 1, 1973, str. 11-17. https://hrcak.srce.hr/168186. Citirano 01.10.2020.
Chicago 17th Edition
Simeon, Vera, Mira Škrinjarić-Špoljar i Katja Wilhelm. "Reactivation of phosphorylated cholinesterases in vitro and protecting effects in vivo of some pyridinium and quinolinium oximes." Arhiv za higijenu rada i toksikologiju 24, br. 1 (1973): 11-17. https://hrcak.srce.hr/168186
Harvard
Simeon, V., Škrinjarić-Špoljar, M., i Wilhelm, K. (1973). 'Reactivation of phosphorylated cholinesterases in vitro and protecting effects in vivo of some pyridinium and quinolinium oximes', Arhiv za higijenu rada i toksikologiju, 24(1), str. 11-17. Preuzeto s: https://hrcak.srce.hr/168186 (Datum pristupa: 01.10.2020.)
Vancouver
Simeon V, Škrinjarić-Špoljar M, Wilhelm K. Reactivation of phosphorylated cholinesterases in vitro and protecting effects in vivo of some pyridinium and quinolinium oximes. Arh Hig Rada Toksikol. [Internet]. 1973 [pristupljeno 01.10.2020.];24(1):11-17. Dostupno na: https://hrcak.srce.hr/168186
IEEE
V. Simeon, M. Škrinjarić-Špoljar i K. Wilhelm, "Reactivation of phosphorylated cholinesterases in vitro and protecting effects in vivo of some pyridinium and quinolinium oximes", Arhiv za higijenu rada i toksikologiju, vol.24, br. 1, str. 11-17, 1973. [Online]. Dostupno na: https://hrcak.srce.hr/168186. [Citirano: 01.10.2020.]

Sažetak
Six pyridinium and quinolinium oximes (I-VI) were tested as reactivators of serum and erythrocyte cholinesterases inhibited with 0-ethyl-S-(2-dimethylaminothioethyl)-methylphosphonate (medemo) and 0-ethyl p-nitrophenyl-ethylphosphonate (armin). They were also tested as protective agents in rats poisoned with l-methyl-2,2-dimethylpropylmethylphos-phonofluoridate (soman) and medemo. The results obtained were compared with the effect of TMB-4. Oxime IV [1.3 acetone-bis (4-pyridinium aldoxime)dichloride] proved to be a good reactivator of erythrocyte cholinesterase inhibited by medemo. Used as a protective agent together with atropine in rat poisoning it increased LD50 of medemo 48 times. Oximes I (1-benzyl-4-pyridinium aldoxime chloride) and III (l-phenacyloxime-2-pyridinium aldoxime chloride) were good reactivators of serum cholinesterase inhibited by armin and medemo. Oximes I and III used together with atropine raised LD50 in rats poisoned with medemo 20 times. Oximes III and II (l-phenacyloxime-2-pyridinium aldoxime chloride) used together with atropine increased LD50 in rats poisoned with soman 2.0 (oxime II) and 1.8 times (oxime III) respectively. Oximes V and VI (1-phenacyloxime-quinolinium chloride and 1-phenacyloxime-isoquinolinium chloride) were very toxic and did not reactivate inhibited cholinesterases at all. The effects of oximes tested were equal to or weaker than those of TMB-4 both in vitro and in viva studies.

Hrčak ID: 168186

URI
https://hrcak.srce.hr/168186

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